Results 151 to 160 of about 3,269,914 (259)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Science is judgment, not only calculation

Erasmus Journal for Philosophy and Economics, 2008
Stephen T. Ziliak, Deirdre Nansen McCloskey   +1 more
doaj   +1 more source

Letter to the "The Effects of Pilates-Based Tele-Exercise on Physical and Mental Health in Primary Dysmenorrhea": Methodological Considerations on the Effects of Pilates-Based Tele-Exercise for Primary Dysmenorrhea: Beyond Statistical Significance. [PDF]

J Obstet Gynaecol Res
Huang J, Zhai X, Zheng X.
europepmc   +1 more source

Geometry-derived statistical significance: A probabilistic framework for detecting true positive findings in MRI data. [PDF]

Brain Behav, 2023
Bansal R, Peterson BS.
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

How the quality of GWAS of human lifespan and health span can be improved

Frontiers in Genetics, 2013
Anatoliy I Yashin, Konstantin G. Arbeev, Deqing eWu, Liubov S. Arbeeva, Alexander M Kulminski, Igor eAkushevich, Irina eCulminskaya, Eric eStallard, Svetlana eUkraintseva   +8 more
doaj   +1 more source

About Research: Clinical Versus Statistical Significance. [PDF]

J Hum Lact
Wouk K, Kenny K, Chetwynd E.
europepmc   +1 more source

One-Sided Multidimensional Statistical Significance Testing: A New Method of Calculating the Statistical Significance of Spectra Used to Demonstrate Magnetic Nanoparticle Sensitivity. [PDF]

J Phys D Appl Phys, 2022
Weaver JB, Weaver CV, Ness DB, Gordon-Wylie SW, Demidenko E.   +4 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Survival-inferred fragility of statistical significance in phase III oncology trials. [PDF]

NPJ Precis Oncol
Sherry AD, Liu Y, Msaouel P, Lin TA, Koong A, Lin C, Abi Jaoude J, Patel RR, Kouzy R, El-Alam MB, Miller AM, Owiwi M, Ofer J, Bomze D, McCaw ZR, Meirson T, Ludmir EB.   +16 more
europepmc   +1 more source