Results 171 to 180 of about 5,906,609 (291)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

About Research: Clinical Versus Statistical Significance. [PDF]

J Hum Lact
Wouk K, Kenny K, Chetwynd E.
europepmc   +1 more source

Replacing statistical significance and non-significance with better approaches to sampling uncertainty. [PDF]

Front Physiol, 2022
Hopkins WG.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Disparity between statistical significance and clinical importance in published randomised controlled trials: a methodological study. [PDF]

BMJ Open
Esterhuizen TM, Mbuagbaw L, Rehman N, Yanwou N, Swaby DJ, Kittle E, Licht JC, Thabane L.   +7 more
europepmc   +1 more source

Statistical Significance Testing for Mixed Priors: A Combined Bayesian and Frequentist Analysis. [PDF]

Entropy (Basel), 2022
Robnik J, Seljak U.
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Data interpretation and statistical significance

Indian Journal of Dental Research, 2019
S M Balaji
doaj   +1 more source

Clinical significance versus statistical significance: Does it matter in clinical practice? [PDF]

Indian J Anaesth
Mohanty CR, Barik AK, David GAJ, Radhakrishnan RV.   +3 more
europepmc   +1 more source

Is it time to stop using statistical significance? [PDF]

Aust Prescr, 2021
Frank O, Tam CM, Rhee J.
europepmc   +1 more source