Results 71 to 80 of about 8,661,639 (296)

Software energy profiling: comparing releases of a software product [PDF]

, 2016
In the quest for energy efficiency of Information and Communication Technology, so far research has mostly focused on the role of hardware. However, as hardware technology becomes more sophisticated, the role of software becomes crucial.
Lago, Patricia, Jan Martijn van der Werf, Brinkkemper, Sjaak, Patricia Lago, Lago, P.; id_orcid, Jagroep, Erik, Rob van Vliet, Procaccianti, G.; id_orcid, Blom, Leen, Procaccianti, Guiseppe, Sub Algemeen Software Systems, Sub Software Production, Brinkkemper, S., Erik A. Jagroep, Leen Blom, Software Production, Blom, L., Giuseppe Procaccianti, van Vliet, Rob, Sjaak Brinkkemper, Jagroep, E.A., van der Werf, J.M.E.M.   +21 more
core   +2 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Spreadsheets in the Cloud - Not Ready Yet

, 2013
Cloud computing is a relatively new technology that facilitates collaborative creation and modification of documents over the internet in real time. Here we provide an introductory assessment of the available statistical functions in three leading cloud ...
McCullough, Bruce D., Yalta, A. Talha
core  

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Mean centering is not necessary in regression analyses, and probably increases the risk of incorrectly interpreting coefficients

Frontiers in Psychology
Scholars trained in the use of factorial ANOVAs have increasingly begun using linear modelling techniques. When models contain interactions between continuous variables (or powers of them), it has long been argued that it is necessary to mean center ...
Lee H. Wurm, Miles Reitan
doaj   +1 more source

Developing Statistical Software in FORTRAN 95

Journal of Statistical Software, 2006
s not available for ...
Robert Gentleman
doaj   +1 more source

Checklist for a Software Management Plan

, 2016
It is easy to concentrate on short-term issues when developing research software. Getting publications, collaboration with others and the demands of a daily research routine can all conspire to prevent proper planning for the development of research ...
The Software Sustainability Institute
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source