Results 61 to 70 of about 5,766,937 (282)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

An Empirical Study on Writer Identification and Verification From Intra-Variable Individual Handwriting

IEEE Access, 2019
The handwriting of a person may vary substantially with factors, such as mood, time, space, writing speed, writing medium/tool, writing a topic, and so on. It becomes challenging to perform automated writer verification/identification on a particular set
Chandranath Adak, Bidyut B. Chaudhuri, Michael Blumenstein   +2 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Graphical User Interfaces for R

Journal of Statistical Software, 2012
Since R was first launched, it has managed to gain the support of an ever-increasing percentage of academic and professional statisticians. However, the spread of its use among novice and occasional users of statistics have not progressed at the same ...
Ruben D. Ledesma, Pedro M. Valero-Mora
doaj  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Selection of Statistical Software for Solving Big Data Problems for Teaching [PDF]

, 2017
The need for analysts with expertise in big data software is becoming more apparent in 4 today’s society. Unfortunately, the demand for these analysts far exceeds the number 5 available. A potential way to combat this shortage is to identify the software
Dou, Min, Li, Yang, Ozgur, Ceyhun, Rogers, Grace   +3 more
core   +2 more sources

RooStatsCms: a tool for analyses modelling, combination and statistical studies

, 2009
The RooStatsCms (RSC) software framework allows analysis modelling and combination, statistical studies together with the access to sophisticated graphics routines for results visualisation.
, ACaldwell, D Piparo, G Quast, G Schott, Goto M, James F, Metzger W J, Moneta L, Piparo D, Read A L, Schott G, The ATLAS experiment, The CMS collaboration, The CMS Collaboration, The CMS Collaboration, The CMS Collaboration, The CMSSW Application Framework, The LEP Electroweak Working Group, The RooStats Project, The Tevatron Electroweak Working Group   +20 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

SPEED Stat: a free, intuitive, and minimalist spreadsheet program for statistical analyses of experiments

Crop Breeding and Applied Biotechnology, 2020
SPEED Stat is a new spreadsheet program for univariate statistical analyses, focused on the dominant profile of agricultural experimentation. The program can perform analysis of variance; tests for normality, homoscedasticity, additivity, outliers ...
André Mundstock Xavier de Carvalho, Felipe Queiroz Mendes, Fabrícia Queiroz Mendes, Laene de Fátima Tavares   +3 more
doaj  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source