Results 81 to 90 of about 1,688,539 (296)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Reporting the standard error of the mean: a critical analysis of three journals in manual medicine

Chiropractic & Manual Therapies
Background In the realm of biomedical research articles, authors typically utilize descriptive statistics to outline the characteristics of their study samples.
Alen Manovic, Ebba Immelsjö, Iben Axen, Per J. Palmgren   +3 more
doaj   +1 more source

Exploring pre-service teachers' understanding of statistical variation: Implications for teaching and research [PDF]

, 2007
Concerns about the importance of variation in statistics education and a lack of research in this topic led to a preliminary study which explored pre-service teachers’ ideas in this area.
Sharma, Sashi
core   +1 more source

Doubly Robust Sure Screening for Elliptical Copula Regression Model

, 2018
Regression analysis has always been a hot research topic in statistics. We propose a very flexible semi-parametric regression model called Elliptical Copula Regression (ECR) model, which covers a large class of linear and nonlinear regression models such
He, Yong, JI, Jiadong, Zhang, Liang, Zhang, Xinsheng   +3 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Public Integrity, Economic Freedom and Governance Performance. A Comparative Study for the EU Member States and Acceding Countries [PDF]

, 2010
The studies concerning the impact of corruption on the effectiveness of governance are numerous, valorising profound approaches, based on criteria and standards related to good governance, organizational behaviour.
Matei, Ani, Savulescu, Carmen.
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Implementing an Executive-Function Syllabus: Operational Issues [PDF]

Journal of Systemics, Cybernetics and Informatics, 2016
A recent approach to pedagogic challenge, contrastive to the hierarchy approach of Bloom, Anderson, Gagne, Van Hiele, Marzano, Webb and many others, identifies pedagogic challenge with executive function: Pedagogy is defined as challenging if it ...
Russell Jay Hendel
doaj  

Quality of China's Official Statistics: A Brief Review of Academic Perspectives

The Copenhagen Journal of Asian Studies, 2017
Following the rise of the Chinese economy, interest in the official statistics coming from China is intensifying. Official data on GDP, industrial production and other economic indicators attracts a lot of attention all over the world.
Dmitriy Plekhanov
doaj   +1 more source