Results 41 to 50 of about 42,879 (261)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
WEATHER AND CLIMATE EXTREMES IN LIGHT OF THE IPCC SREX (2011) AND BEYOND [PDF]
Aerul şi Apa: Componente ale Mediului, 2012 Weather and climate extremes in light of the IPCC SREX (2011) and beyond. The recent IPCC Special Report (IPCC SREX, 2011) provides a comprehensive overview of meteorological (i.e. weather and climate) extremes and their various aspects.
JÁNOS MIKA
doaj
Extreme dry and wet events in Iceland: Observations, simulations and scenarios
Meteorologische Zeitschrift, 2007 Monthly extremes of dryness and wetness in Iceland are analysed based on the standardised precipitation index (SPI). The analysis is performed for observations and four sets of coupled atmosphere-ocean climate model simulations (ECHAM5/MPI-OM) to link ...
Frank Sienz +3 more
doaj +1 more source
Local impact analysis of climate change on precipitation extremes: are high-resolution climate models needed for realistic simulations? [PDF]
Hydrology and Earth System Sciences, 2016 This study explores whether climate models with higher spatial resolutions provide higher accuracy for precipitation simulations and/or different climate change signals.
H. Tabari +8 more
doaj +1 more source
Statistics of extremes by oracle estimation
The Annals of Statistics, 2008 We use the fitted Pareto law to construct an accompanying approximation of the excess distribution function. A selection rule of the location of the excess distribution function is proposed based on a stagewise lack-of-fit testing procedure. Our main result is an oracle type inequality for the Kullback--Leibler loss.
Grama, Ion, Spokoiny, Vladimir
openaire +5 more sources
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Relations between electron contentand peak density: regular and extreme behaviour
Annals of Geophysics, 2004 Electron content statistics offers important information for planning and operation of various application systems that make use of the transionospheric propagation of radio signals.
S. S. Kouris +4 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source