Results 101 to 110 of about 8,442,055 (315)

Detection of Rehabilitation Training Effect of Upper Limb Movement Disorder Based on MPL-CNN

open access: yesSensors
Stroke represents a medical emergency and can lead to the development of movement disorders such as abnormal muscle tone, limited range of motion, or abnormalities in coordination and balance. In order to help stroke patients recover as soon as possible,
Lijuan Shi   +4 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Brief to the Ontario Status of Women Council and the Attorney-General

open access: yes
The Ontario Committee on the Status of Women, a grassroots feminist group, was established in 1970. Its purpose was to seek implementation in Ontario of the Recommendations of the Royal Commission on the Status of ...
Ontario Committee on the Status of Women
core  

Brief to Ontario Human Rights Commission

open access: yes, 1976
The Ontario Committee on the Status of Women, a grassroots feminist group, was established in 1970. Its purpose was to seek implementation in Ontario of the Recommendations of the Royal Commission on the Status of ...
Ontario Committee on the Status of Women
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Community Attitudes Towards Domestic Violence, Australia, 1987

open access: yes, 2019
In December 1987 a national survey was conducted to assess community attitudes towards domestic violence in Australia. The objectives of the survey were to broadly assess community perceptions on domestic violence; to identify key issues or attitudes ...
Office of the Status of Women
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Submission to Government of Ontario

open access: yes
The Ontario Committee on the Status of Women, a grassroots feminist group, was established in 1970. Its purpose was to seek implementation in Ontario of the Recommendations of the Royal Commission on the Status of ...
Ontario Committee on the Status of Women   +1 more
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

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