Results 191 to 200 of about 32,338 (260)

Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková   +3 more
wiley   +1 more source

Seizures in children with Dravet syndrome in extreme heat: A qualitative study of parental perspectives

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Perspectives of parents of children with Dravet syndrome indicate that extreme heat and high temperatures exacerbate epileptic seizures, introduce new seizure triggers, and require the adoption of specific seizure‑management strategies. Abstract Aim To describe parental perspectives on how heatwaves and high ambient temperatures influence seizure ...
Angel Aledo‐Serrano   +8 more
wiley   +1 more source

Peri-Ictal MRI Abnormalities and Risk of Unprovoked Seizures After De Novo Status Epilepticus. [PDF]

open access: yesNeurology
Orav K   +8 more
europepmc   +1 more source

Neuroimaging and neurophysiology in infantile‐onset epilepsy after neonatal stroke

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
This population‐based retrospective cohort study of 55 newborn infants demonstrated that neonatal MRI and neonatal neurophysiology (amplitude‐integrated EEG, conventional EEG, and somatosensory evoked potentials) combined with follow‐up EEGs during the first year of life provide practical tools for identifying infants at the highest risk of developing ...
Sinikka La Grassa   +6 more
wiley   +1 more source

Presumptive Acute Post‐Hypoxic Myoclonus Following Return of Spontaneous Circulation in a Cat and a Dog

open access: yesJournal of Veterinary Emergency and Critical Care, EarlyView.
ABSTRACT Objective To describe the clinical presentation of presumptive acute post‐hypoxic myoclonus in a cat and a dog after cardiopulmonary arrest (CPA). In people, acute post‐hypoxic myoclonus is a transient focal, multifocal, or generalized rhythmic myoclonus that results from global hypoxic–ischemic brain injury and may be cortical or subcortical ...
Theofanis Liatis   +2 more
wiley   +1 more source

Respiratory dysfunction and fatal apnea during pilocarpine-induced status epilepticus. [PDF]

open access: yesEpilepsia
Sun C   +6 more
europepmc   +1 more source

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