Results 121 to 130 of about 698,757 (298)

Perancangan dan Analisa Sistem Kendali Frekuensi Sistem Tenaga Listrik dengan Metode Penempatan Kutub [PDF]

, 2017
This study discusses the application of Polar Placement method using Bass - Gura algorithm on Non - Reheat type frequency electric control system with emphasis on frequency deviation on power system.
Laksono, H. D. (Heru), Pratama, A. P. (Aditya)   +1 more
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Enzyme as Maxwell's Demon: Steady-state Deviation from Chemical Equilibrium by Enhanced Enzyme Diffusion

Enhanced enzyme diffusion (EED), in which the diffusion coefficient of an enzyme transiently increases during catalysis, has been extensively reported experimentally. We numerically and analytically demonstrate that such enzymes can act as Maxwell's demons.
Ichii, Shunsuke, Hatakeyama, Tetsuhiro S., Kaneko, Kunihiko   +2 more
openaire   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Supervised Reinforcement Learning-Based Collaborative Master–Slave Harvest Control Study in Wheat

Agronomy
Aiming at the difficulty of controlling the longitudinal relative position of agricultural machines during the agricultural master–slave navigation cooperative operation and the weak adaptability of the unitary traditional control method in the face of ...
Zhikai Ma, Chao Zhang, Wei Wang, Hao Wang, Helong Yu, Chunjiang Zhao   +5 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Simulation-Based Analysis of DRL Exploitation Rate for Voltage and Frequency Stability in a Single-Inverter Microgrid Control System

IEEE Access
This paper discusses the development and performance evaluation of a single-inverter-based microgrid control system using a Deep Reinforcement Learning (DRL) agent trained with the Twin Delayed Deep Deterministic Policy Gradient (TD3) algorithm.
Noer Fadzri Perdana Dinata, Makbul Anwari Muhammad Ramli, Muhammad Irfan Jambak, Prisma Megantoro, Muhammad Abu Bakar Sidik   +4 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Research on Bumpless Transfer Control Methods Between Steady-State and Transient-State Operations in Aero-Engines

Aerospace
Online performance optimization improves fuel economy in modern aero-engines, but shifts in the steady operating point require authority handovers between steady and transient controllers.
Ruichao Li, Jinghao Yao, Zhicheng Zhou, Jiale Wang, Chao Wu   +4 more
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source