Results 81 to 90 of about 1,771,897 (325)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Modeling and simulation of drying operation in PVC powder production line: a pneumatic dryer model [PDF]

, 2012
A one-dimensional steady-state model is developed to simulate drying of PVC powder in a pneumatic dryer. In this model, a two-phase continuum model was used to describe the steady-state flow of a dilute dispersed phase (wet PVC powder) and a continuous ...
Ansart, Renaud, Aubin, Antoine, Branly, Marc, Hemati, Mehrdji, Lasuye, Thierry   +4 more
core  

Fast Transient Boundary Control and Steady-State Operation of the Dual Active Bridge Converter Using the Natural Switching Surface

IEEE transactions on power electronics, 2014
This paper presents a boundary control scheme for dual active bridge (DAB) converters using the natural switching surface (NSS). The implementation of a curved switching surface for DAB converters is a new area of research undertaken in this paper.
G. Oggier, M. Ordonez, J. M. Gálvez, F. Luchino   +3 more
semanticscholar   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Numerical investigation of double-flame hot-water boilers under steady-state operation

International Journal of Thermofluids
This study investigates the optimal arrangement of combustion chambers in double-flame hot-water boilers using computational fluid dynamics (CFD) under steady-state and laminar conditions. The study considers two arrangements: horizontal and vertical. In
Diyar Karimi, Rahim Hassanzadeh
doaj   +1 more source

Assessment of a quantum phase gate operation based on nonlinear optics

, 2006
We analyze in detail the proposal for a two-qubit gate for travelling single-photon qubits recently presented by C. Ottaviani \emph{et al}. [Phys. Rev. A \textbf{73}, 010301(R) (2006)].
C. Ottaviani, D. Vitali, E. Arimondo, G. Di Giuseppe, G. P. Agrawal, H. J. Carmichael, J. I. Cirac, M. A. Nielsen, P. Tombesi, S. Rebić   +9 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Improving the Energy Efficiency of Operation of a Multi-Motor Plate Conveyor in the Steady-State Operation Mode

Communications
The established mode of operation of the conveyor with a nominal linear load is the most economically advantageous from the point of view of increasing the energy efficiency of mineral transportation, in which the cargo flow with minerals corresponds to ...
Adilbek Kazbekovich Kelisbekov, Nurlan Asylkhanovich Daniyarov, Baurzhan Gilymovich Moldabaev   +2 more
doaj   +1 more source

Operation-Adaptive Damage Assessment of Steam Turbines Using a Nonlinear Creep-Fatigue Interaction Model

IEEE Access, 2020
For sustainable operation, power plants require accurate damage assessment of the steam turbines used for power generation. In the past few decades, steam turbine designs have considered only steady-state operation, without accounting for thermal cyclic ...
Woosung Choi, Heonjun Yoon, Byeng Dong Youn   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source