Results 61 to 70 of about 48,477 (300)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Towards detachment-compatible I-mode plasma on EAST tokamak

Nuclear Fusion
The divertor detachment is important for the improved confinement mode (I-mode) to serve as a reliable operating scenario in future fusion reactors. A reproducible steady-state I-mode operation with the energy detachment of the inner target has been ...
L. Yu, L. Wang, X.L. Zou, X. Lin, L.Y. Meng, Q.Q. Yang, X.M. Zhong, L.Q. Xu, A.D. Liu, R.R. Liang, Z.Q. Zhou, K.D. Li, Q. Zang, L. Zhang, T.F. Zhou, Y.M. Duan, Y.F. Jin, T.Q. Jia, M.R. Wang, H.Q. Liu, B. Zhang, G.S. Xu, Z.X. Liu, Y.T. Song, EAST I-mode Working Group, the EAST Team   +25 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Study of Partial-Phase Steady-State Operation Modes of Phase-Shift Transformer with Hexagonal Circuit and Regulating Autotransformer

Problems of the Regional Energetics, 2021
The scope of the work was the study of the phase failure operating for the new FACT’s type phase-shifting device, intended for the flexible connection of AC power systems. The mathamatical model has been developed for conducting this study. The device contains the main phase-shifting transformer based on hexagon circuit with additional regulating ...
Bosneaga V., Suslov V.
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

ANALYTICAL AND MODEL STUDY OF ACTIVE SEMICONDUCTOR CONVERTER IN ELECTRICAL DRIVE SYSTEMS [PDF]

Научно-технический вестник информационных технологий, механики и оптики, 2014
Mathematical description of the active semiconductor converter based on the main (smooth) component method and method of resulting vector is proposed.
S. G. German-Galkin, Z. C. Zwierzewicz, N. A. Polyakov   +2 more
doaj  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Transient power equalization control strategy of virtual synchronous generator in isolated island microgrid with heterogeneous power supply

Scientific Reports, 2023
In the parallel supply system of synchronous generator and virtual synchronous generator, the physical structure and control structure of the two kinds of power supply are quite different, and it is difficult to distribute the transient power of the two ...
Changwei Gao, Yongchang Sun, Weiqiang Zheng, Wei Wang   +3 more
doaj   +1 more source

Single- and Multi-Objective Optimization of a Dual-Chamber Microbial Fuel Cell Operating in Continuous-Flow Mode at Steady State [PDF]

Processes, 2020
Microbial fuel cells (MFCs) are a promising technology for bioenergy generation and wastewater treatment. Various parameters affect the performance of dual-chamber MFCs, such as substrate flow rate and concentration. Performance can be assessed by power density ( PD ), current density ( CD ) production, or substrate removal efficiency ...
openaire   +3 more sources