Results 51 to 60 of about 22,533,400 (291)
Simulation of steady – state heat process for the rectangular fin – containing system
Mathematical Modelling and Analysis, 1999 In this paper three analytical solution for 2D temperature distribution in the wall and fin are considered solution. The results of calculations are compared with the analytical. Stacionaraus šilumos laidumo proceso modeliavimas stačiakamrėse srityse
M. Buike
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Application of single Hall chip in short circuit current detection of DC system
Energy Reports, 2022 For the short circuit current test requirement of copper platoon at the entrance of a hybrid current-limiting fuse, the magnetic field distribution simulation model of copper platoon in both steady and transient current state were built. The influence of
Haibo Yue +6 more
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FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
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How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
The Steady State Fluctuation Relation for the Dissipation Function [PDF]
, 2007 We give a proof of transient fluctuation relations for the entropy production (dissipation function) in nonequilibrium systems, which is valid for most time reversible dynamics. We then consider the conditions under which a transient fluctuation relation
Bernhardt, Debra +13 more
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Energy-saving optimization on active disturbance rejection decoupling multivariable control
Nuclear Engineering and Technology, 2023 An industrial control process multiple-input multiple-output (MIMO) coupled system is analyzed in this study as an example of a Loss of Coolant Accident (LOCA) simulation system.
Da-Min Ding +4 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
, 2017 <p>This is the archive of simulation inputs and python scripts used in the manuscript Perne, M., Covington, M.D., Thaler, E.A., and J.M. Myre (2017).
Matt Covington
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