Results 51 to 60 of about 386,892 (315)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Steady-state and tracking analysis of the SSLMS algorithm
, 2018 This paper presents expressions for the steady-state mean-square error (MSE), the optimum stepsize, and the corresponding minimum value of the tracking MSE of the sign-sign least mean square (SSLMS) algorithm for the case of real-valued data.
Zerguine, A., Ulla Faiz, M.
core +1 more source
Simulation of steady-state cuttings transport through a horizontal annulus channel
EPJ Web of Conferences, 2019 The current study is devoted to simulating cuttings transport by drilling fluid through a horizontal section of borehole with an annular cross section. Drill pipe rotates in fixed eccentric position. Steady-state flow is considered.
Ignatenko Yaroslav +3 more
doaj +1 more source
Application of single Hall chip in short circuit current detection of DC system
Energy Reports, 2022 For the short circuit current test requirement of copper platoon at the entrance of a hybrid current-limiting fuse, the magnetic field distribution simulation model of copper platoon in both steady and transient current state were built. The influence of
Haibo Yue +6 more
doaj +1 more source
Automated estimation and variance reduction for steady-state simulations [PDF]
Proceedings of the 18th conference on Winter simulation - WSC '86, 1986 We present an automated procedure that interfaces with SIMSCRIPT II.5 simulation experiments to derive point and interval estimators for steady-state parameters of stochastic simulations. The procedure combines the nonoverlapping batch means method of output analysis and the control variates variance reduction technique. Batch size and control variates
Rowena Añonuevo, Barry L. Nelson
openaire +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Lap time simulation for racing car design [PDF]
, 2002 Racing teams use numerous computational tools (CAD, FEA, CFD) to aid in the design of racing cars and the development of their performance. Computer simulation of racing car handling through Lap Time Simulation (LTS) packages complements these tools. It
Siegler, Blake
core
Steady-state performance analysis of a variable tap-length LMS algorithm [PDF]
, 2008 A steady-state performance analysis of the fractional tap-length (FT) variable tap-length least mean square (LMS) algorithm is presented in this correspondence. Based on the analysis, a mathematical formulation for the steady-state tap length is obtained.
Li, N +7 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source