Results 71 to 80 of about 871,293 (307)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Steady-State Creep of Asphalt Concrete
Applied Sciences, 2017 This paper reports the experimental investigation of the steady-state creep process for fine-grained asphalt concrete at a temperature of 20 ± 2 °С and under stress from 0.055 to 0.311 MPa under direct tension and was found to occur at a constant rate ...
Alibai Iskakbayev +2 more
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The steady-states of splitter networks
CoRRWe introduce splitter networks, which abstract the behavior of conveyor belts found in the video game Factorio. Based on this definition, we show how to compute the steady-state of a splitter network. Then, leveraging insights from the players community, we provide multiple designs of splitter networks capable of load-balancing among several conveyor ...
Couëtoux, Basile +2 more
openaire +4 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Heliyon, 2018 The efficiency by which animals utilize dietary energy is fundamental to the cost of production for protein of animal origin and to the carbon footprint an animal industry has.
A.L. Schaefer +11 more
doaj +1 more source
Analysis of Steady-state Characteristics of Thermal Subsystem in Integrated Energy System
发电技术, 2020 The integrated energy system (IES) includes various energy forms, complex operation modes, abundant control equipment and coupling links, which brings challenges to its steady-state modeling and steady-state power flow calculation. In order to obtain the
Lu QU +4 more
doaj +1 more source
, 2022 A) The steady-state value of PSCs calculated by the analytical formula (blue line) accurately fits to the steady-state responses (red dots) of the discrete TM model (calculated for the 100th stimulation pulse).
Leon Amadeus Steiner (13839877) +4 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source