Results 71 to 80 of about 170,525 (342)

Insulin-like Growth Factor Binding Proteins and Cellular Senescence Are Involved in the Progression of Non-Alcoholic Fatty Liver Disease and Fibrosis in a Mouse Model

Medicina
Background and Objectives: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. It progresses from simple steatosis to non-alcoholic steatohepatitis (NASH).
Carolina Guzmán, Miriam G. Bautista-Ubaldo, Adriana Campos-Espinosa, Ivette I. Romero-Bello, Ángel Daniel Santana-Vargas, Gabriela Gutierrez-Reyes   +5 more
doaj   +1 more source

Lipotoxic lethal and sublethal stress signaling in hepatocytes: relevance to NASH pathogenesis[S]

Journal of Lipid Research, 2016
The accumulation of lipids is a histologic and biochemical hallmark of obesity-associated nonalcoholic fatty liver disease (NAFLD). A subset of NALFD patients develops progressive liver disease, termed nonalcoholic steatohepatitis, which is characterized
Petra Hirsova, Samar H. Ibrabim, Gregory J. Gores, Harmeet Malhi   +3 more
doaj   +1 more source

Evaluation of the role of kefir in management of non-alcoholic steatohepatitis rat model via modulation of NASH linked mRNA-miRNA panel [PDF]

, 2023
Noha Salah, Sanaa Eissa, Amal Mansour, Nagwa M Abo El Magd, Amany Helmy Hasanin, Manal M. El Mahdy, Mohamed K. Hassan, Marwa Matboli   +7 more
openalex   +1 more source

Liver transplantation for alcoholic cirrhosis: Long term follow-up and impact of disease recurrence [PDF]

, 2001
Background. Alcoholic liver disease has emerged as a leading indication for hepatic transplantation, although it is a controversial use of resources. We aimed to examine all aspects of liver transplantation associated with alcohol abuse.
Andrea M. DiMartini, Anthony J. Demetris, Ashok Jain, Balan, Bassendine, Becker, Belle, Bellentani, Beresford, Beresford, Beresford, Berlakovich, Bernard, Bizollon, Blakolmer, Campbell, Chao, Christopher O.C. Bellamy, Conjeevaram, Cromie, Duvoux, Enomoto, Everhart, Everson, Fauerholdt, Ferrell, Forrest Dodson, Foster, Gane, Graziadei, Harrison, Hoofnagle, Howard, Iezzoni, Ishak, Jain, John J. Fung, Keeffe, Kenngott, Kris Ruppert, Kumar, Kyriacou, Lee, Levin, Levy, Lucey, Lucey, Lucey, Mendenhall, Michael Torbenson, Nabel, Neuberger, Neuberger, Neuberger, Osorio, Pageaux, Pappo, Pereira, Reed, Reich, Saunders, Schiff, Seitz, Sherlock, Shev, Starzl, Tang, Thomas E. Starzl, Tringali, Uchimura, Wiesner, Yates   +71 more
core   +1 more source

Hepatic ferroptosis plays an important role as the trigger for initiating inflammation in nonalcoholic steatohepatitis

Cell Death and Disease, 2019
Nonalcoholic steatohepatitis (NASH) is a metabolic liver disease that progresses from simple steatosis to the disease state of inflammation and fibrosis.
Shinya Tsurusaki, Y. Tsuchiya, T. Koumura, Misaki Nakasone, Taro Sakamoto, Masaki Matsuoka, H. Imai, Cindy Yuet-Yin Kok, H. Okochi, H. Nakano, A. Miyajima, Minoru Tanaka   +11 more
semanticscholar   +1 more source

Cordycepin Ameliorates Nonalcoholic Steatohepatitis by Activation of the AMP‐Activated Protein Kinase Signaling Pathway

Hepatology, 2021
Nonalcoholic fatty liver disease, especially nonalcoholic steatohepatitis (NASH), has become a major cause of liver transplantation and liver‐associated death.
T. Lan, Yang Yu, Jing Zhang, Haonan Li, Qiqing Weng, Shuo Jiang, S. Tian, Tonghao Xu, Shan Hu, Guizhi Yang, Yan Zhang, Weixuan Wang, Lexun Wang, Qing Zhu, X. Rong, Jiao Guo   +15 more
semanticscholar   +1 more source

CRISPR‐MI and scRNA‐Seq Reveal TREM2's Function in Monocyte Infiltration and Macrophage Apoptosis During Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
A method is developed for conducting genome‐wide CRISPR/Cas9 screening of monocyte infiltration in vivo (CRISPR‐MI) that is easily adaptable across a variety of disease models. Through the combination of CRISPR‐MI and scRNA‐Seq, this study discovers that Trem2 is a key regulator of early monocyte infiltration in abdominal aortic aneurysm (AAA ...
Haocheng Lu, Chao Xue, Yang Zhao, Jinjian Sun, Changzhi Zhao, Xu Zhang, Guizhen Zhao, Yaozhong Liu, Hongyu Liu, Yongjie Deng, Ying Wang, Chi Zhang, Yingjie Liu, Linjun Zeng, Ying Yang, Bolun Li, Shusi Ding, Linkang Zhou, Henry Kuang, Zanxin Wang, Wenhao Ju, Haihuan Lin, Jie Lin, Yanhong Guo, Lin Chang, Hongmei Zhao, Jing Wang, Jiandie Lin, Lemin Zheng, Y. Eugene Chen, Jifeng Zhang   +30 more
wiley   +1 more source

Macrophage‐derived MLKL in alcohol‐associated liver disease: Regulation of phagocytosis

Hepatology, EarlyView., 2022
EtOH causes leaky gut allowing bacteria and PAMPs into the liver, resulting in hepatic inflammation and injury. We demonstrate that LPS induces STAT1‐mediated expression and phosphorylation of MLKL in macrophages and identify a novel function that myeloid MLKL translocates to phagosomes and lysosomes and regulates phagocytosis, which contributes to the
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy   +16 more
wiley   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source