Nonalcoholic steatohepatitis pharmacotherapy and predictors of response: dual role of aminotransferases as biosensors of metabolism and biomarkers of histological improvement [PDF]
, 2019 Nonalcoholic steatohepatitis (NASH)—the severe histological form of nonalcoholic fatty liver disease (NAFLD)—is regarded as a major health problem worldwide (1,2).
Pirola, Carlos José +1 more
core +1 more source
Empagliflozin is associated with improvements in liver enzymes potentially consistent with reductions in liver fat: results from randomised trials including the EMPA-REG OUTCOME® trial [PDF]
, 2018 Aims/hypothesis: In addition to beneficial effects on glycaemia and cardiovascular death, empagliflozin improves adiposity indices. We investigated the effect of empagliflozin on aminotransferases (correlates of liver fat) in individuals with type 2 ...
Fitchett, David +4 more
core +1 more source
Emerging Insights into the Role of BDNF on Health and Disease in Periphery
BiomoleculesBrain-derived neurotrophic factor (BDNF) is a growth factor that promotes the survival and growth of developing neurons. It also enhances circuit formation to synaptic transmission for mature neurons in the brain.
Mayuko Ichimura-Shimizu +5 more
doaj +1 more source
A new non-invasive method for assessing steatosis in chronic liver diseases [PDF]
Терапевтический архив, 2016 Aim. To assess the diagnostic accuracy of the controlled attenuation parameter (CAP) to determine the grade of hepatic steatosis (HS) in patients with chronic liver diseases (CLD) of different etiologies and to compare the obtained results with ...
I G Bakulin +3 more
doaj
Steatohepatitis in Children with Obesity
Вопросы современной педиатрии, 2021 The article discusses the issues of steatohepatitis development, diagnosis, and management in children. Steatohepatitis is one of the forms of non-alcoholic fatty liver disease diagnosed in 12–26% of children with obesity.
Alexander A. Zvyagin +3 more
doaj +1 more source
Deficiency of the purinergic receptor 2X7 attenuates nonalcoholic steatohepatitis induced by high-fat diet. possible role of the NLRP3 Inflammasome [PDF]
, 2017 Molecular mechanisms driving transition from simple steatosis to nonalcoholic steatohepatitis (NASH), a critical step in the progression of nonalcoholic fatty liver disease (NAFLD) to cirrhosis, are poorly defined. This study aimed at investigating the
Blasetti Fantauzzi, Claudia +6 more
core +3 more sources
Российский кардиологический журнал, 2023 Aim. To assess the characteristics of ST-segment elevation myocardial infarction (STEMI) in patients with metabolic syndrome (MS) in the presence and absence of metabolic-associated fatty liver disease (MAFLD).Material and methods.
V. A. Tretyakova +5 more
doaj +1 more source
Role of High-Mobility Group Box-1 in Liver Pathogenesis [PDF]
, 2019 High-mobility group box 1 (HMGB1) is a highly abundant DNA-binding protein that can relocate to the cytosol or undergo extracellular release during cellular stress or death. HMGB1 has a functional versatility depending on its cellular location.
Huda, Nazmul +3 more
core +1 more source
Liver transplantation for alcoholic cirrhosis: Long term follow-up and impact of disease recurrence [PDF]
, 2001 Background. Alcoholic liver disease has emerged as a leading indication for hepatic transplantation, although it is a controversial use of resources. We aimed to examine all aspects of liver transplantation associated with alcohol abuse.
Andrea M. DiMartini +71 more
core +2 more sources
Sinusoidal cell–derived biomarker scores predict diagnosis and prognosis in chronic liver disease
BMC MedicineBackground Sinusoidal cells are central drivers of chronic liver disease (CLD) progression, yet current biomarkers fail to capture their phenotypic states.
Sergi Guixé-Muntet +6 more
doaj +1 more source