Results 41 to 50 of about 137,068 (205)

The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease

Frontiers in Physiology, 2012
Alcoholic liver disease (ALD) encompasses hepatic steatosis, which may progress to alcoholic hepatitis, fibrosis, and cirrhosis. It remains a leading cause of morbidity and mortality in the US and worldwide.
Phillipp eHartmann, Wei-Chung eChen, Bernd eSchnabl   +2 more
doaj   +1 more source

Reduced expression of chemerin in visceral adipose tissue associates with hepatic steatosis in patients with obesity [PDF]

, 2016
Objective: This study aimed to evaluate whether circulating levels and/or visceral adipose tissue (VAT) expression of recently described adipokines associate with histopathological severity of nonalcoholic fatty liver disease (NAFLD), independent of ...
Alfadda, Behari, Bekaert, Bozaoglu, Brunt, Bugianesi, Chakaroun, Deng, Docke, Donnelly, Ehrlund, Fuster, Greulich, Gruben, Haukeland, Heiker, Kanda, Kim, Kleiner, Luangsay, Mahdi, Marchesini, Musso, Ouwens, Polyzos, Polyzos, Rivera, Saxena, Seki, Sell, Sell, Souza Batista, Wittamer, Wittamer, Wolfs, Wong, Yang, Yilmaz, Zelber-Sagi, Zeng   +39 more
core   +1 more source

Fibrosis activity vs. disease stage: Complementary and independent predictors of outcomes in alcohol-related liver disease

JHEP Reports
Background & Aims: Excessive alcohol consumption accelerates fibrosis progression in steatotic liver disease. Disease activity can be described by fibrogenic activity, of which collagen formation is a central process. Type III collagen formation (PRO-
Stine Johansen, Mads Israelsen, Katrine Holtz Thorhauge, Johanne Kragh Hansen, Camilla Dalby Hansen, Helle Lindholm Schnefeld, Peter Andersen, Ida Villesen, Katrine Tholstrup Bech, Sönke Detlefsen, Nikolaj Torp, Diana Leeming, Maja Thiele, Aleksander Krag, Morten Karsdal   +14 more
doaj   +1 more source

New Rat Model of Advanced NASH Mimicking Pathophysiological Features and Transcriptomic Signature of The Human Disease

Cells, 2019
Non-alcoholic steatohepatitis (NASH) is a major cause of chronic liver disease. However, most available animal models fail to reflect the whole spectrum of the disease.
Raquel Maeso-Díaz, Zoe Boyer-Diaz, Juan José Lozano, Martí Ortega-Ribera, Carmen Peralta, Jaime Bosch, Jordi Gracia-Sancho   +6 more
doaj   +1 more source

Pathology of steatohepatitis

Best Practice & Research Clinical Gastroenterology, 2002
Pathologists have long been involved in clinical diagnosis and investigative studies of various forms of liver disease, including alcoholic liver disease. The concept that progressive fatty liver disease may result from causes other than alcohol toxicity can be noted in the literature.
Brunt, EM, Tiniakos, DG
openaire   +3 more sources

Infections increase the risk of decompensation and death in patients with early alcohol-related liver disease

JHEP Reports
Background & Aims: Infections are frequent in patients with cirrhosis and worsen prognosis. We evaluated the incidence of infections and their impact on decompensation and death in patients with early alcohol-related liver disease (ALD) during long ...
Stine Johansen, Simon Langkjær, Ditlev Nytoft Rasmussen, Mads Israelsen, Nikolaj Torp, Katrine Lindvig, Maria Kjærgaard, Johanne Kragh Hansen, Camilla Dalby Hansen, Katrine Thorhauge, Peter Andersen, Sönke Detlefsen, Helene Bæk Juel, Ulrik Stenz Justesen, Torben Hansen, Aleksander Krag, Maja Thiele, Ema Anastasiadou, Manimozhian Arumugam, Peer Bork, Torben Hansen, Jenny Presto, Hans Israelsen, Morten Karsdal, Cristina Legido-Quigley, Hans Olav Melberg, Maja Thiele, Jonel Trebicka, Aleksander Krag, Peer Bork, Mathias Mann, Jelle Matthijnssens, Aleksander Krag, Torben Hansen   +33 more
doaj   +1 more source

Insulin resistance associates with hepatic lobular inflammation in subjects with obesity [PDF]

, 2019
Purpose: Obese subjects with nonalcoholic fatty liver disease (NAFLD) are more prone to develop additional metabolic disturbances such as systemic insulin resistance (IR) and type 2 diabetes.
Batens, Arsène-Hélène, Bekaert, Marlies, Geerts, Anja, Hoorens, Anne, Lapauw, Bruno, Ouwens, Margriet, Shadid, Samiah, Van de Velde, Frederique, Van Nieuwenhove, Yves   +8 more
core   +1 more source

Non-invasive tests for MetALD and alcohol-related liver diseaseKeypoints

JHEP Reports
Summary: Metabolic- and alcohol-related liver disease (MetALD) and alcohol-related liver disease (ALD) are major drivers of the global burden of cirrhosis. While metabolic dysfunction-associated steatotic liver disease (MASLD) affects nearly one-third of
Stine Johansen, Maja Thiele, Aleksander Krag   +2 more
doaj   +1 more source

Immune and Inflammatory Pathways in Non-Alcoholic Steatohepatitis (NASH). An update [PDF]

, 2019
Non-alcoholic steatohepatitis (NASH), also known as fatty liver disease (FLD), is a major public health problem. It is considered to be the hepatic manifestation of the metabolic syndrome.
Breaban, Iulia, Coste, Sorina Cezara, Cozma, Angela, Negrean, Vasile, Orasan, Olga Hilda, Popovici, Ionela, Procopciuc, Lucia Maria, Sampelean, Dorel, Sitar Taut, Adela, Stefan, Andreea Maria, Tarmure Sarlea, Simina   +10 more
core   +1 more source

Bifidobacteria and lactobacilli in the gut microbiome of children with non-alcoholic fatty liver disease: which strains act as health players? [PDF]

, 2018
Introduction: Non-alcoholic fatty liver disease (NAFLD), considered the leading cause of chronic liver disease in children, can often progress from non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH).
Alisi, A, Chierico, Fd, Cucchiara, S, Drago, Lorenzo, Mosca, A, Nobili, V, Putignani, L, Stronati, L, Toscano, M, Vernocchi, P   +9 more
core   +3 more sources