Validation of Intravoxel Incoherent Motion MRI Using Perfused Explanted Human Livers
Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose Evaluate the feasibility of using perfused explanted human livers for validating intravoxel incoherent motion (IVIM). Methods Eight (n = 8) explanted livers from deceased donors were obtained. The portal vein and hepatic artery of each explanted liver were connected to a perfusion system.
Gregory Simchick +6 more
wiley +1 more source
Developing a non-invasive algorithm for the diagnosis of steatotic liver disease in primary healthcare: a retrospective cohort study. [PDF]
BMJ Health Care InformSpencer-Sandino M +14 more
europepmc +1 more source
Highly Reproducible, Vendor‐Agnostic, Motion‐Insensitive Liver PDFF Mapping at 0.55T, 1.5T, and 3T
Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose To develop and validate a vendor‐agnostic, motion‐insensitive proton‐density fat‐fraction (PDFF) quantification method. Methods Flip‐angle‐modulated (FAM) 2D chemical‐shift‐encoded (CSE) MRI for PDFF quantification was implemented in both the vendor‐agnostic platform Pulseq (“Pulseq‐FAM”) and one vendor‐specific platform (“GE‐specific ...
Jiayi Tang +27 more
wiley +1 more source
Hepatic Steatosis: A Presentation of Cholesteryl Ester Storage Disease. [PDF]
ACG Case Rep JLee A +5 more
europepmc +1 more source
Nanoformulated Diacerein Alleviates Hyperlipidemia via Gut Microbiota Modulation In Vivo
Nano Select, EarlyView.A nanoformulation of diacerein (Nano‐DIA) was fabricated with carboxymethyl cellulose, achieving enhanced solubility and rapid dissolution for alternative anti‐hyperlipidemia therapeutics. Mechanistic studies revealed its in vivo lipid‐lowering efficacy is through metabolite‐mediated and microbiota‐dependent manner, highlighting its dual action on host
Zheng Peng +8 more
wiley +1 more source
Metabolic Syndrome Fuels Genomic Instability? Insights from a Pilot Study on Colorectal Cancer. [PDF]
Cancers (Basel)Pezzino S +7 more
europepmc +1 more source
Obesity, EarlyView.ABSTRACT Objective In this study, we investigated the effects of a stem cell‐derived secretome product on adiposity and tissue quality and insulin and glucose levels in obese mice and those undergoing dietary weight loss. Methods Following 16 weeks of high fat diet mice received acute (4 weeks) biweekly intramuscular injections with vehicle or ...
Zachary J. Fennel +11 more
wiley +1 more source
Accuracy of attenuation coefficient measurement (ACM) for hepatic steatosis: comparison with MRI proton density fat fraction (MRI-PDFF) and chemical fat analysis using multimodal liver fat phantoms. [PDF]
Front Med (Lausanne)Zhaivoronok M +4 more
europepmc +1 more source