Results 321 to 330 of about 236,526 (353)

Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis

open access: yesNature Biotechnology, 2023
The lack of registered drugs for nonalcoholic fatty liver disease (NAFLD) is partly due to the paucity of human-relevant models for target discovery and compound screening.
Delilah F G Hendriks, Jos F Brouwers
exaly   +2 more sources

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

open access: yesNature Medicine, 2018
Hepatic steatosis is a multifactorial condition that is often observed in obese patients and is a prelude to non-alcoholic fatty liver disease. Here, we combine shotgun sequencing of fecal metagenomes with molecular phenomics (hepatic transcriptome and ...
L Hoyles   +2 more
exaly   +2 more sources

Accuracy of FibroScan Controlled Attenuation Parameter and Liver Stiffness Measurement in Assessing Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

open access: yesGastroenterology, 2019
BACKGROUND & AIMS We estimated the accuracy of FibroScan vibration-controlled transient elastography controlled attenuation parameter (CAP) and liver stiffness measurement (LSMs) in assessing steatosis and fibrosis in patients with suspected nonalcoholic
Peter Eddowes   +2 more
exaly   +2 more sources
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Cellular senescence drives age-dependent hepatic steatosis

open access: yesNature Communications, 2017
The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial dysfunction. Senescent cells
Mikolaj Ogrodnik   +2 more
exaly   +2 more sources

Magnetic Resonance Imaging More Accurately Classifies Steatosis and Fibrosis in Patients With Nonalcoholic Fatty Liver Disease Than Transient Elastography

open access: yesGastroenterology, 2016
BACKGROUND & AIMS Noninvasive methods have been evaluated for the assessment of liver fibrosis and steatosis in patients with nonalcoholic fatty liver disease (NAFLD).
Kento Imajo   +2 more
exaly   +2 more sources

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