Results 61 to 70 of about 198,724 (360)
Research on the Species Difference of the Hepatotoxicity of Medicine Based on Transcriptome
Frontiers in Pharmacology, 2021 In recent years, several drugs have been withdrawn from use by regulatory bodies owing to hepatotoxicity; therefore, studies on drug-induced liver injury (DILI) are being actively pursued. Most studies evaluating DILI use rats or mice as animal models to
Ziying Xu +7 more
doaj +1 more source
Vitamin D to reduce liver fibrosis in non-alcoholic fatty liver disease [PDF]
, 2017 BACKGROUND: As the prevalence of metabolic risk factors in the American population has increased over time, so too has the diagnoses of non-alcoholic fatty liver disease (NAFLD).
Fox, Ryan
core
GSH Attenuates Organ Injury and Improves Function after Transplantation of Fatty Livers [PDF]
, 2010 Ischemia-reperfusion injury (IRI) is increased after transplantation of steatotic livers. Since those livers are increasingly used for transplantation, protective strategies must be developed. Reactive oxygen species (ROS) play a key role in hepatic IRI.
Angele, M. K. +7 more
core +1 more source
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Current Issues in Molecular BiologyNonalcoholic steatohepatitis (NASH) is characterized by severe inflammation and fibrosis due to an excessive accumulation of triglycerides (TGs) in the liver with a dysregulated de novo lipogenesis (DNL) pathway.
Nam-Hee Kim +7 more
doaj +1 more source
Cell Reports, 2017 The liver has a large capacity for mitochondrial fatty acid β-oxidation, which is critical for systemic metabolic adaptations such as gluconeogenesis and ketogenesis.
Jieun Lee +7 more
doaj +1 more source
Correlation of Ultrasound Acoustic Radiation Force Impulse Elastography with Sonographic Severity Grading of Fatty Liver Disease [PDF]
Journal of Clinical and Diagnostic Research, 2018 Introduction: Fatty liver is one of the commonly encountered incidental finding in routine ultrasonography practice. The fatty liver has been divided into three grades according to severity based on the degree of increased liver echotexture on ...
Varsha P Rangankar +3 more
doaj +1 more source
Advanced Functional Materials, EarlyView.Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu +3 more
wiley +1 more source
Food & Nutrition Research, 2018 Background: Augmenting glucose utilization in skeletal muscle via the phosphatidylinositol-3 kinase (PI3 kinase)/protein kinase B (Akt) pathway or the adenosine monophosphate (AMP)-activated protein kinase (AMPK) pathway is necessary to regulate ...
Ui-Jin Bae +4 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2021 Background and Aims: Activation of the inflammasome NLRP3 (NOD-, LRR- and pyrin domain containing 3) contributes to the development of non-alcoholic fatty liver disease (NAFLD) and progression to non-alcoholic steatohepatitis (NASH).
Sandra Torres +21 more
doaj +1 more source