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Role of steatotic liver disease in prediction and prevention of cardiometabolic diseases
Nature Reviews Gastroenterology & Hepatology, 2023 Steatotic liver disease has emerged as an important risk factor for cardiovascular disease, type 2 diabetes mellitus and chronic kidney disease. Successful treatment of steatotic liver disease might also be effective in preventing these cardiometabolic diseases.
Norbert Stefan +2 more
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Lipid droplets in steatotic liver disease
Current Opinion in Clinical Nutrition & Metabolic Care, 2023Purpose of review This review aims to discuss the most recent evidence exploring the role of lipid droplets in steatotic liver disease (SLD). We highlight the breadth of mechanisms by which lipid droplets may contribute to the progression of SLD with a particular focus on the role of lipid droplets as inducers of mechanical ...
Josh, Bilson, Eleonora, Scorletti
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Longitudinal Clinical Outcomes and Mortality from Steatotic Liver Disease: A Meta-Analysis
American Journal of MedicineIntroduction: The updated consensus introduces steatotic liver disease as an umbrella term for all patients with hepatic steatosis, with specific subtypes such as metabolic dysfunction-associated steatotic liver disease (MASLD), MetALD (MASLD with ...
Do Han Kim
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Role of Neutrophils in the Development of Steatotic Liver Disease
Seminars in Liver DiseaseThis review explores the biological aspects of neutrophils, their contributions to the development of steatotic liver disease, and their potential as therapeutic targets for the disease. Although alcohol-associated and metabolic dysfunction-associated liver diseases originate from distinct etiological factors, the two diseases frequently share ...
You-Jin, Choi +2 more
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Steatotic Liver Disease: Pathophysiology and Emerging Pharmacotherapies
Pharmacological ReviewsSteatotic liver disease (SLD) displays a dynamic and complex disease phenotype. Consequently, the metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction-associated steatohepatitis (MASH) therapeutic pipeline is expanding rapidly and in multiple directions.
Michail Kokkorakis +6 more
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Editorial: Crystalising the burden of steatotic liver disease
Alimentary Pharmacology & TherapeuticsLINKED CONTENTThis article is linked to Schneider et al papers.
Luis Calzadilla Bertot, Leon A. Adams
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Steatotic Liver Diseases (SLDs): A Review
Journal of Insurance MedicineLiver steatosis is now the politically correct term for excessive fat in the liver (fatty liver). Its incidence and prevalence, in lockstep with diabetes and obesity, continue to climb to over 2 billion persons worldwide. It is the most common cause of chronic liver disease and the leading cause of liver-related morbidity and mortality. This treatise,
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Liver and atherosclerotic risks of patients with cryptogenic steatotic liver disease
Hepatology InternationalIn 2023, a new nomenclature of "metabolic associated steatotic liver disease" (MASLD) has emerged by incorporating cardio-metabolic criteria to redefine "non-alcoholic fatty liver disease" (NAFLD). Among steatotic liver disease (SLD), those having no known causes and without any one of cardio-metabolic criteria are deemed to have cryptogenic SLD.
Shao-Wen Wang +4 more
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Detecting at-risk steatotic liver disease and liver fibrosis in the community
HepatologyAdvanced liver fibrosis and “At-Risk” metabolic dysfunction-associated steatohepatitis (At-Risk MASH) are present in 5% and 10%, respectively, of community-based patients with steatotic liver disease and metabolic risk factors and/or excess alcohol consumption.
Leon A. Adams +2 more
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Precision medicine in steatotic liver disease
Current Opinion in GastroenterologyPurpose of review Discuss advances in genomics, metabolomics, and proteomics in steatotic liver disease. Recent findings Common genetic variants in genes including PNPLA3
Vitchapong Prasitsumrit, Vincent L. Chen
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