Results 61 to 70 of about 21,054 (225)

Magnesium as a conformational gatekeeper of KRAS: Structural dynamics and therapeutic implications

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Magnesium serves as an essential cofactor for small GTPases, yet its structural role in regulating KRAS conformational dynamics and nucleotide exchange remains poorly understood. Here, we combine hydrogen–deuterium exchange mass spectrometry (HDX‐MS), native mass spectrometry, and functional assays to elucidate how Mg2+ stabilizes the KRAS ...
Bindu Y. Srinivasu, Tanvi S. Damerla, Alexander Stec, Zhiwei Zhou, John R. Engen, Kenneth D. Westover, Thomas E. Wales   +6 more
wiley   +1 more source

Genomic epidemiology and lineage‐specific risk stratification of tet(X4)‐mediated tigecycline resistance along the pork production chain: A One Health perspective

iMetaOmics, Volume 3, Issue 2, June 2026.
Genome surveillance across a swine‐associated One Health continuum in China shows that slaughterhouses act as major enrichment nodes for tet(X4)‐mediated tigecycline resistance, driven by putative clonal transmission and stable plasmid backbones. Integrating global datasets enables lineage‐specific risk stratification, highlighting key control points ...
Qin Wang, Qiwu Yuan, Xuan Chen, Yujing Zhong, Ke Wu, Renqiao Wen, Luya Liu, Xiaoqin Wang, Cui Li, Hongning Wang, Changwei Lei   +10 more
wiley   +1 more source

Detection of Cleaved Stx2a in the Blood of STEC-Infected Patients

Toxins, 2023
Typical hemolytic uremic syndrome (HUS) is mainly caused by Shiga toxin-producing Escherichia coli (STEC) releasing Shiga toxin 2 (Stx2). Two different structures of this AB5 toxin have been described: uncleaved, with intact B and A chains, and cleaved, with intact B and a nicked A chain consisting of two fragments, A1 and A2, connected by a disulfide ...
Elisa Varrone, Domenica Carnicelli, Xiaohua He, Marco Grasse, Karin Stampfer, Silke Huber, Sára Kellnerová, Pier Luigi Tazzari, Francesca Ricci, Paola Paterini, Gianluigi Ardissino, Stefano Morabito, Dorothea Orth-Höller, Reinhard Würzner, Maurizio Brigotti   +14 more
openaire   +4 more sources

Emerging Dissemination of blaCTX‐M‐65 in Bovine E. coli in Spain Associated With IncHI2 Plasmids

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
The resistome in ESBL/AmpC‐producing E. coli in livestock was diverse and dominated by plasmid‐borne genes Detection of host‐independent dissemination of AMR determinants mediated by shared plasmid types First report in Spanish cattle of blaCTX‐M‐65 on IncHI2 plasmids, an under‐reported ESBL in Europe Identification of potentially zoonotic clones in ...
Medelin Ocejo, Beatriz Oporto, Ana Hurtado   +2 more
wiley   +1 more source

Top-Down Proteomic Identification of Shiga Toxin 1 and 2 from Pathogenic Escherichia coli Using MALDI-TOF-TOF Tandem Mass Spectrometry

Microorganisms, 2019
Shiga-toxin-producing Escherichia coli (STEC) are a burden on agriculture and a threat to public health. Rapid methods are needed to identify STEC strains and characterize the Shiga toxin (Stx) they produce.
Clifton K. Fagerquist, William J. Zaragoza, Michelle Q. Carter   +2 more
doaj   +1 more source

Culture-free detection and enumeration of STEC in water

Ecotoxicology and Environmental Safety, 2011
Shiga toxin-producing Escherichia coli (STEC) causes worldwide outbreaks of food and waterborne diseases. Rapid identification of causative agents is critical for early intervention in the case of widespread diarrheal epidemics to prevent mortality.
S, Ram, P, Vajpayee, P D, Dwivedi, R, Shanker   +3 more
openaire   +2 more sources

Molecular Detection and Antibiotic Susceptibility Pattern of Shiga Toxin Producing Escherichia coli among Children with Diarrhea in Addis Ababa, Gondar, and Harar, Ethiopia

Journal of Medical Microbiology and Infectious Diseases
Introduction: Shiga toxin-producing Escherichia coli (STEC) is a major cause of pediatric diarrhea globally, yet its burden, molecular characteristics, and antibiotic resistance patterns remain underexplored in low-resource settings like Ethiopia ...
Amete Mihret Teshale, Alem Abrha Kalayu, Degefu Beyene, Eyasu Tigabu, Woldaregay Erku Abegaz   +4 more
doaj   +1 more source

Prevalence, Antimicrobial Resistance, and Resistance Gene Profiles of Extended‐Spectrum β‐Lactamase‐Producing Escherichia coli and Klebsiella pneumoniae Isolated From Quails in Sylhet, Bangladesh

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
This study investigated the molecular epidemiology and antimicrobial resistance of Escherichia coli and Klebsiella pneumoniae isolated from quails in Bangladesh. High prevalence of E. coli, including Shiga toxin‐producing strains, and widespread multidrug resistance were observed.
Md. Al Mamun, Hemayet Hossain, Md. Shahidur Rahman Chowdhury, Shahida Begum Nargis, Munni Rani Das, Rakibul Hasan, Nasrin Akter Liza, Shuvojit Mitra, Md Bashir Uddin, Md. Mukter Hossain, Md. Mahfujur Rahman   +10 more
wiley   +1 more source

The paradigm of ground meat as source of STEC in high risk area of HUS from Argentina [PDF]

, 2019
Objectives: The aim of this work is to evaluate ground meat as infection source of Shiga toxin-producing Escherichia coli (STEC) to population of Tierra del Fuego, Argentina.Background: Argentina is the country with the highest rate of hemolytic uremic ...
Bentancor, Adriana Beatriz, Broglio, Alicia Susana   +1 more
core   +1 more source

Supplementary data for: "High mitochondrial diversity in a new water bear species (Tardigrada: Eutardigrada) from mountain glaciers in central Asia, with the erection of a new genus Cryoconicus"

Supplementary data for description of the new tardigrade genus and species Cryoconicus kaczmareki gen et sp. nov.: "S1_Accesion Numbers" contains GenBank accession numbers of seqences used in this study; "S2_Haplotypes & p-distances" contains list of ...
Stec, Daniel
core   +2 more sources