Results 51 to 60 of about 606,028 (294)

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Experimental study of the bond behavior of 400MPa grade hot-rolled ribbed steel bars in steel fibre reinforced concrete

open access: yesScientific Reports
Present studies show that steel fibres can improve the bond of steel bar in steel fibre reinforced concrete (SFRC) with a correlation to the fibre factor and the fibre distribution uniformity.
Minglei Zhao   +4 more
doaj   +1 more source

Behavior of Reinforcing Bar Connection of Hollow-Core Slabs to Steel Beams under In-Plane Forces

open access: yesCivilEng, 2022
Hollow-core slab (HCS) floors supported on steel beams require the use of steel reinforcement as connections to avoid slab displacement caused by lateral loads.
Susana Hernandez Brito   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Insights into the effect of H2S on the corrosion behavior of N80 steel in supercritical CO2 environment

open access: yesJournal of Materials Research and Technology, 2023
In this study, the corrosion behavior of N80 steel exposed to 80 bar supercritical CO2 and 0–15 bar H2S environments was investigated by weight loss test, surface analysis, water chemistry simulation, corrosion thermodynamic and kinetic calculations. The
Chong Sun   +5 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Ultra-High Strength 50SiMnCr Spring Flat Steel and its Continuous Cooling Transformation Behavior [PDF]

open access: yesTeshugang
The development and application of ultra-high strength spring flat steel is of great significance in achieving automotive lightweight. Understanding the continuous cooling transformation behavior of this type of steel aids in developing its post-hot ...
Hou Shiyao, Zhang Yang, Yang Dongou, Zhao Yang, Chen Liqing
doaj   +1 more source

Analysis of bond-slip between concrete and steel bar in fire [PDF]

open access: yes, 2016
This paper presents a robust model for predicting the bond-slip between the concrete and steel reinforced bar at elevated temperatures. The model is established based on a partly cracked thick-wall cylinder theory and the smeared cracking approach is ...
Fan, M, Huang, Z, Jamal, K
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Research on Structural Parameter Optimization and Springback Compensation Methods of a Steel Bar Hoop Bending Machine

open access: yesApplied Sciences, 2023
After being processed into a certain shape by a stirrup bending machine, steel bars are used as the skeleton of reinforced concrete in construction. The accuracy of their bending directly affects the bearing capacity of reinforced concrete.
Jianxiong Wei   +3 more
doaj   +1 more source

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