Results 71 to 80 of about 606,028 (294)
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Radiometer-deployment subsystem [PDF]
, 1972 A radiometer-deployment subsystem for the Nimbus E spacecraft was designed, developed, and qualified for space use. The dimensions of the radiometer are 0.9 meter square by 0.1 meter, and its weighs 32 kilograms.
Speight, K. M.
core +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Study Of structural Behaviour And Residual Drift Of Concrete frames Reinforced With Shape Memory Alloy Rebar [PDF]
Journal of Structural and Construction Engineering, 2019 Buildings in high seismic regions are prone to severe damage and collapse during earthquakes due to large lateral deformations. The use of superelastic shape memory alloys (SMAs) as reinforcements in concrete structures is gradually gaining interest ...
Masoud Mirtaheri +3 more
doaj +1 more source
The role of lipid metabolism in neuronal senescence
FEBS Open Bio, EarlyView.Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
MetalsShape memory alloys (SMAs) demonstrate a shape memory effect and superelasticity that can provide recovery performance to structural members. In this study, a round SMA bar was designed to replace the conventional deformed steel bar, particularly within ...
Min-Kyu Song, Eunsoo Choi, Jong-Han Lee
doaj +1 more source
Pengaruh Pembengkokan terhadap Kekuatan Baja Sruktur Tulangan Beton di Lingkungan Air Gambut [PDF]
, 2015 Concrete reinforcement steel bar when it began ordering from manufacturers and further functionalized into the building structure experience bending process to ease the transportation activity or while loading and unloading is not willful bent ...
Dalil, M. (M), Ikhwan, K. S. (Kana)
core
Impact Strength Of Glass And Glass Ceramic [PDF]
, 2009 Strength of glass and glass ceramic was measured with a bar impact technique. High-speed movies show regions of tensile and compressive failure. The borosilicatc glass had a compressive strength of at least 2.2 GPa, and the glass ceramic at least 4 GPa ...
Bless, S., Tolman, J.
core +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source