Results 231 to 240 of about 29,584 (314)

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, EarlyView.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

Object Detection and Recognition Based on Deep Learning. [PDF]

Sensors (Basel)
Carletti V, Saggese A, Spagnolo P.
europepmc   +1 more source

In‐Process Magnetization for 3D Printing of Magnetorheological Elastomer with Heterogeneous Magnetic Profile for Anisotropic Actuation

Advanced Science, EarlyView.
Fully programmable, in‐process 3D magnetization integrated with multi‐material printing enables soft magnetic systems with precise actuation and sensing. Discrete and continuous magnetization profiles drive bending, morphing, and locomotion, demonstrated through strain‐sensing elements, dragonfly‐inspired wings, octopus‐like tentacles, and a serpentine
Phillip Glass, David Hassouna, Udena Epitawala Arachchige, Hyeon Yun Jeong, Sung Hyun Park, Daeha Joung   +5 more
wiley   +1 more source

Robust computer-vision based construction site detection for assistive-technology applications. [PDF]

Disabil Rehabil Assist Technol
Feng J, Hamilton-Fletcher G, Ballem N, Batavia M, Wang Y, Zhong J, Beheshti M, Porfiri M, Rizzo JR.   +8 more
europepmc   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

Lateral Resistance of Modular CFS Shear Wall Connected with Rectangular Steel Tubes and Its Contribution to Frame Structures. [PDF]

Materials (Basel)
Kang Y, Mei J, Wu X, Wang L.
europepmc   +1 more source

Retinomorphic Visual Processing Enabled by Contact‐Engineered IGZO Optoelectronic Synaptic Memtransistors

Advanced Science, EarlyView.
Here, we present an optoelectronic synaptic memtransistor (OSMT) integrating photoresponsive IGZO with contact‐engineered HfO2, enabling electrically and optically tunable synaptic weights. The device demonstrates broad range of tunable conductance states and array‐level image processing, highlighting its potential for intelligent machine vision ...
Donghyun Kang, San Nam, Dayul Nam, In‐Soo Kim, Myung‐Gil Kim, Sung Kyu Park, Yong‐Hoon Kim   +6 more
wiley   +1 more source

Seismic Performance of Recycled Aggregate Concrete-Filled Steel Tube Column-Composite Beam Frames with Column-End Stirrup Confinement. [PDF]

Materials (Basel)
Yang Z, Chen X, Xu H, Hui B, Huang J, Wang L, Sadat SI, Ding F.   +7 more
europepmc   +1 more source