Results 51 to 60 of about 96,811 (268)

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian   +6 more
wiley   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra   +5 more
wiley   +1 more source

Effect of Initial Plate Thickness and Reduction on Cladding Ratio of Hot-Rolled Clad Steel Plate

open access: yesTeshugang, 2014
Effect of the initial cladding ratio 5.40%-15.53% with 0.45C steel, NM360 abrasion-resistant steel, 310S and 316 stainless steel 5.1-15.2 mm initial cladding plate and Q345 carbon steel 82.7-90.0 mm initial base plate and the total reduction 35%-75% on ...
李龙, 张心金, 祝志超, 李萌蘖
doaj  

The Comprehensive Live Cell‐Based Cytotoxicity Assay for Monitoring Disease Activity and Guiding Rescue Therapy in Acute Attacks of NMOSD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a devastating neurological disease that lacks serological biomarkers that can accurately reflect disease activity. We established a live cell‐based assay (LCBA) using serum with endogenous complement to quantify the overall cytotoxicity, offering a novel functional tool for monitoring
Xiaona Xu   +10 more
wiley   +1 more source

Structural Performance of Composite Shear Walls under Compression

open access: yesApplied Sciences, 2017
In order to research the effect of different layout forms of steel plate on the axial compression behavior of a steel plate-concrete composite shear wall, this paper presents the experimental results and analysis of the axial compression behavior of a ...
Tingyue Hao   +4 more
doaj   +1 more source

Alzheimer's Disease Biomarkers Measured by Capillary Blood Collection Versus Venous Plasma and Cerebrospinal Fluid

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Blood biomarkers are increasingly critical for non‐invasive Alzheimer's Disease (AD) diagnostics and research but typically require on‐site processing. Remote point‐of‐care collection methods could enhance biomarker testing in clinical and research settings.
Sara Ho   +9 more
wiley   +1 more source

Elasto-plastic Buckling Analysis of Novel Origami-inspired Steel Plate Shear Wall with Two-side Connections

open access: yes工程科学与技术, 2018
Existing steel plate shear walls could not meet the requirements of high mechanical properties and energy dissipation performance at the same time. To solve this problem, based on the origami theory three kinds of novel pre-folded steel plate shear walls
Jinyu LU, Ding LU, Xudong QIAO
doaj  

Finite Element Analysis of L-shaped Double Steel Plate Composite Shear Wall

open access: yes工程科学与技术, 2021
The double steel plate composite shear wall structure is widely used in the high-rise buildings due to its advantages of good integrity, high rigidity and high shear bearing capacity.
Jian LI   +3 more
doaj  

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai   +13 more
wiley   +1 more source

Investigation on Tempering Process of 45Mn2V/Q345 Clad Steel Plate for Saw Blade

open access: yesTeshugang, 2020
Tempering of the holding time after different temperature of clad steel plate for saw blade steel has been carried out, the hardness of cladding plate and hase plate and the microstructure evolution are measured and observed.
杨跃辉   +4 more
doaj  

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