Results 71 to 80 of about 90,749 (265)

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A study on using electric power steering to reduce the effort required for handling

open access: yesNihon Kikai Gakkai ronbunshu, 2016
This paper proposes a design method that uses electric power steering (EPS) to reduce the effort required for handling in a vehicle. To accomplish this, the design must reduce the physical effort required of the driver, improve the controllability of ...
Shuji ENDO
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

No-backlash control system by two-motor drive (The analyses of backlash occurrence mechanism)

open access: yesNihon Kikai Gakkai ronbunshu, 2015
We analyze backlash occurrence mechanism of a no-backlash drive control technique in which two motors drive a load axis, as one is for a plus direction and another is for a minus direction, into the simulation and the experiment.
Akihiro MAEKAWA, Yusuke SUGIURA
doaj   +1 more source

IMPROVING THE SYSTEM OF VEHICLE STEERING

open access: yesVestnik OrelGAU, 2015
The article describes the requirements for steering systems and a construction of the steering, which would eliminate sidewise skidding of car and improve its stability when moving on turn. The use of this system allows reducing the centrifugal effect resulting in the sideslip at the initial stage of coming into corner.
openaire   +2 more sources

Compliant control of steer-by-wire systems

open access: yes2009 IEEE/ASME International Conference on Advanced Intelligent Mechatronics, 2009
Vehicle directional control and driver interaction assemblies have been built to study and implement impedance control strategies on a steer-by-wire system. Adaptive on-line estimation is used to identify the dynamic parameters of vehicle directional control and driver interaction assemblies.
Cetin, A. Emre   +3 more
openaire   +4 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

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