Results 11 to 20 of about 2,486 (97)

Intrinsic MicroRNA-10a Restricts Regulatory T Cell Suppressive Function and Intestinal Repair by Coordinating Transcriptional, Metabolic, and Epithelial Repair Pathways. [PDF]

Adv Sci (Weinh)
This study identifies microRNA‐10a (miR‐10a) as a key brake on regulatory T cell (Treg) suppressive function and intestinal repair. By targeting Blimp‐1, Uqcrq, and amphiregulin, miR‐10a restrains transcriptional, metabolic, and epithelial programs essential for Treg activity.
Yang W, Yu T, Yang H, Yao S, Ma R, Steinert EM, Ridge KM, Cui W, Chandel NS, Cong Y.   +9 more
europepmc   +2 more sources

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

Between Emancipation and Domination? A Critical Analysis of Empowerment in a Women‐Only Development Program in Costa Rica's Coffee Sector

Sustainable Development, EarlyView.
ABSTRACT Female empowerment and its use in development contexts has histories in coloniality. Gender programs typically imply an individualistic, depoliticized concept. This article examines whether such initiatives can be supportive for empowerment. We apply an embedded qualitative case study of Bean Voyage's program to support female coffee producers
Annelie M. Gütte, Maria Busse, Stefan Sieber, Michelle Bonatti   +3 more
wiley   +1 more source

Unfinished business: A grounded theory analysis of change among individuals classified as numerical non‐responders to psychodynamic psychotherapy for post‐traumatic stress disorder related to childhood maltreatment

Psychology and Psychotherapy: Theory, Research and Practice, EarlyView.
Abstract Objectives Individuals with post‐traumatic stress disorder related to childhood maltreatment (PTSD‐CM) show limited response to treatment on pre‐post‐symptom measures. While a nuanced understanding of nonresponse is crucial for improving treatment, quantitative measures may not fully capture clinically meaningful processes of change from the ...
Fatima Nöske, Frederike Döring, Manfred E. Beutel, Melissa Hitzler, Jürgen Hoyer, Elena Kabbathas, Christine Knaevelsrud, Iris‐T. Kolassa, Johannes Kruse, Falk Leichsenring, Nina Marin, Helen Niemeyer, Simone Salzer, Karoline Sauer, Marie Siebert, Rudolf Stark, Visal Tumani, Kerstin Weidner, Jörn von Wietersheim, Wolfgang Wöller, Christiane Steinert   +20 more
wiley   +1 more source

Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley   +1 more source

Genetic Alterations Involved in Immune Escape Mechanisms of Circulating Tumour Cells in Colorectal Carcinogenesis

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT In colorectal cancer (CRC), circulating tumour cells (CTCs) employ genetic alterations to dodge the body's immune system. These alterations occur in specific “driver” genes, including KRAS, BRAF, p53, MYC, APC and PTEN. Changes in these genes can control how the tumour interacts with the immune system and influence the expression of immune ...
Sharmin Aktar, Matthew Masoudi, Dilpreet Moti, Vinod Gopalan, Farhadul Islam, Alfred King‐yin Lam   +5 more
wiley   +1 more source

Fear in Public Policy Compliance: Citizens' Response to Crisis‐Induced Policies

European Policy Analysis, Volume 12, Issue 2, Spring 2026.
ABSTRACT This article brings together social psychology and public policy literature in a mixed‐methods research design to explore how fear influences non‐compliance with challenging policies during crises. Building on Terror Management Theory, we argue that fear affects individual citizens' compliance tendencies.
Stella Ladi, Kirsty Gardiner, Angelos Angelou, Dimitra Panagiotatou   +3 more
wiley   +1 more source

Floral stage optimization and immune evasion enhance Agrobacterium‐mediated genome editing in Arabidopsis

New Phytologist, Volume 249, Issue 4, Page 2125-2139, February 2026.
Summary Agrobacterium‐mediated transformation by floral inoculation (AMT‐FI) enables genetic engineering without tissue culture. It is widely used in the model plant Arabidopsis thaliana, yet its efficiency and broader applicability remain limited. Here, we used a dual‐reporter system (RUBY and hygromycin resistance) to identify key floral stages and ...
Mao‐Sen Liu, Teng‐Kuei Huang, Yi‐Chieh Wang, Si‐Chong Wang, Chih‐Hang Wu, Chih‐Horng Kuo, Erh‐Min Lai   +6 more
wiley   +1 more source

Re‐evaluation of sucralose (E 955) as a food additive and evaluation of a new application on extension of use of sucralose (E 955) in fine bakery wares

EFSA Journal, Volume 24, Issue 2, February 2026.
Abstract The present opinion deals with the re‐evaluation of sucralose (E 955) as food additive and with the safety of a proposed extension of use in food category (FC) 7.2 ‘Fine bakery wares’. Based on the available data, no safety concerns arose for genotoxicity of sucralose (E 955) and its impurities and degradation products.
EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Lourdes Bastos, Polly Boon, Biagio Fallico, Rex FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Monika Batke, Antonios Douros, James Chipman, Riccardo Crebelli, Peter Fürst, Thorhallur Halldorsson, Manuela Mirat, Alicja Mortensen, Matthew Wright, Oliver Lindtner, Stefania Barmaz, Consuelo Civitella, Zsuzsanna Horvath, Sara Levorato, Elena Mazzoli, Josef Daniel Rasinger, Ana Maria Rincon, Camilla Smeraldi, Alexandra Tard, Federica Lodi   +36 more
wiley   +1 more source

Health Correlates of Extended Longevity in Captive Ring‐Tailed Lemurs (Lemur catta)

American Journal of Primatology, Volume 87, Issue 12, December 2025.
Male and female ring‐tailed lemurs exhibit distinct patterns of age‐related change in certain serum chemistry markers. Photo by David Haring. ABSTRACT Captive primates maintained at accredited institutions can live extraordinarily long lives and, as a result, are useful models for understanding the physiology of aging. Many institutions monitor primate
Ruby L. Mustill, Laura N. Ellsaesser, Cathy V. Williams, Megan Petersdorf, Lydia K. Greene   +4 more
wiley   +1 more source