Results 41 to 50 of about 16,022 (139)
The role of the Amyloid Precursor Protein mutations and PERK-dependent signaling pathways in the pathogenesis of Alzheimer’s disease [PDF]
, 2016 Alzheimer’s disease (AD) is a highly complex, progressive, age-related neurodegenerative human disease entity. The genetic basis of AD is strictly connected with occurrence of mutations in Amyloid Precursor (APP) gene on chromosome 21.
Diehl, J. Alan +5 more
core +2 more sources
Role of genetic aspect in pathogenesis of atopic dermatitis [PDF]
, 2013 The pathogenesis of atopic dermatitis (AD) is a very complicated process that involves an intricate array of molecules. Nowadays it is generally accepted that cytokines play an important role in the progression of the clinical presentation of atopic ...
Wesserling Martyna
core +2 more sources
Sustainable Development, Volume 34, Issue 2, Page 2427-2442, April 2026.ABSTRACT Female empowerment and its use in development contexts has histories in coloniality. Gender programs typically imply an individualistic, depoliticized concept. This article examines whether such initiatives can be supportive for empowerment. We apply an embedded qualitative case study of Bean Voyage's program to support female coffee producers
Annelie M. Gütte +3 more
wiley +1 more source
Predictive validity of the HCR-20 for inpatient aggression:the effect of intellectual disability on accuracy [PDF]
, 2015 BackgroundPeople with intellectual disability (ID) account for a large proportion of aggressive incidents in secure and forensic psychiatric services.
Dickens, G. L. +4 more
core +3 more sources
Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)
ChemMedChem, Volume 21, Issue 5, 13 March 2026.DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley +1 more source
Role of Artificial Intelligence (AI) art in care of ageing society: focus on dementia [PDF]
, 2019 open access articleBackground: Art enhances both physical and mental health wellbeing. The health benefits include reduction in blood pressure, heart rate, pain perception and briefer inpatient stays, as well as improvement of communication skills and ...
Harwood, Tracy +2 more
core +1 more source
Cancer Medicine, Volume 15, Issue 3, March 2026.ABSTRACT In colorectal cancer (CRC), circulating tumour cells (CTCs) employ genetic alterations to dodge the body's immune system. These alterations occur in specific “driver” genes, including KRAS, BRAF, p53, MYC, APC and PTEN. Changes in these genes can control how the tumour interacts with the immune system and influence the expression of immune ...
Sharmin Aktar +5 more
wiley +1 more source
Economic Burden for Lung Cancer Survivors in Urban China. [PDF]
, 2017 BackgroundWith the rapid increase in the incidence and mortality of lung cancer, a growing number of lung cancer patients and their families are faced with a tremendous economic burden because of the high cost of treatment in China.
Du, Jian +10 more
core +2 more sources
Fear in Public Policy Compliance: Citizens' Response to Crisis‐Induced Policies
European Policy Analysis, Volume 12, Issue 2, Spring 2026.ABSTRACT This article brings together social psychology and public policy literature in a mixed‐methods research design to explore how fear influences non‐compliance with challenging policies during crises. Building on Terror Management Theory, we argue that fear affects individual citizens' compliance tendencies.
Stella Ladi +3 more
wiley +1 more source
The system of genetic exchange in Trypanosoma brucei and other trypanosomatids [PDF]
, 2007 In this chapter, we discuss our current understanding of the systems of genetic exchange in trypanosomatids and the im-pact the recent genome projects have had on this area of research.
MacLeod, A., Tait, A., Turner, C.M.R.
core