Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
Multiple Populations in Star Clusters
We review the multiple population (MP) phenomenon of globular clusters (GCs): i.e., the evidence that GCs typically host groups of stars with different elemental abundances and/or distinct sequences in photometric diagrams.
Antonino P. Milone, Anna F. Marino
doaj +1 more source
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
The Interaction Between Accretion from the Interstellar Medium and Accretion from the Evolved Binary Component in Barium Stars [PDF]
The reanalysis of the previously published abundance pattern of mild barium star HD202109 (ζ Cyg) and the chemical compositions of 129 thin disk barium stars facilitated the search for possible correlations of different stellar parameters with second ...
Yeuncheol Jeong +2 more
doaj +1 more source
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
Barium Abundances of Common Stars in the Gaia-ESO Survey and the LAMOST Medium-resolution Survey
Barium (Ba) abundance has been used as a crucial tracer of both slow and rapid neutron-capture processes to constrain the evolutionary models of the Galaxy.
Tian-Yi Chen +8 more
doaj +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Limitations of Stellar Abundance Determinations [PDF]
The information content of (photospheric) stellar spectra and the accuracy of abundance determinations are discussed. Besides the physical properties of the line spectra, the spectral resolution, the signal-to-noise ratio, but also the incompleteness of the knowledge of the contributing blends limit the abundance information.
openaire +1 more source
Atomic diffusion and mixing in old stars IV: Weak abundance trends in the globular cluster NGC 6752 [PDF]
Atomic diffusion in stars can create systematic trends of surface abundances with evolutionary stage. Globular clusters offer useful laboratories to put observational constraints on this theory as one needs to compare abundances in unevolved and evolved ...
Barklem, Paul S. +7 more
core +5 more sources
Hematopoietic (stem) cells—The elixir of life?
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source

