Results 71 to 80 of about 63,717 (277)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

What Physical Factors Influence the Transformation between Blue Supergiants and Red Supergiants?

The Astrophysical Journal
The post-main-sequence evolution of massive stars is highly sensitive to key stellar model parameters, particularly initial rotational velocity and metallicity.
Yun He, Hanfeng Song, Georges Meynet, Andre Maeder, Ruiyu Zhang, Ying Qin, Shitao Qi, Qingli Li, Qiong Zhan   +8 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Metallicities from High-resolution TRES Spectra with uberMS: Performance Benchmarks and Literature Comparison

The Astrophysical Journal Supplement Series
As the field of exoplanetary astronomy has matured, demand has grown for precise stellar abundances to probe subtle correlations between stellar compositions and planetary demographics.
Emily K. Pass, Phillip A. Cargile, Victoria DiTomasso, Romy Rodríguez Martínez, David Charbonneau, David W. Latham, Andrew Vanderburg, Allyson Bieryla, Samuel N. Quinn, Lars A. Buchhave   +9 more
doaj   +1 more source

Properties of WNh stars in the Small Magellanic Cloud: evidence for homogeneous evolution

, 2008
We derive the physical properties of three WNh stars in the SMC to constrain stellar evolution beyond the main sequence at low metallicity and to investigate the metallicity dependence of the clumping properties of massive stars.
Bouret, J. C., Depagne, E., Foellmi, C., Hillier, D. J., Marchenko, S., Martins, F., Moffat, A. F.   +6 more
core   +3 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Blue Supergiants in the Pinwheel Galaxy M101: Comparison with H II Region Chemical Abundances, Spectroscopic Distance, and an Independent Determination of the Hubble Constant

The Astrophysical Journal
We present a quantitative spectroscopic study of 13 blue supergiant stars in the Pinwheel Galaxy M101, based on data obtained with the Low Resolution Imaging Spectrometer available at the Keck I telescope.
Fabio Bresolin, Rolf-Peter Kudritzki, Miguel A. Urbaneja, Eva Sextl, Adam G. Riess   +4 more
doaj   +1 more source

Predictions for complex distributions of stellar elemental abundances in low-mass galaxies [PDF]

, 2022
P. Patel, Sarah Loebman, Andrew Wetzel, Claude‐André Faucher‐Giguère, Kareem El-Badry, Jeremy Bailin   +5 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Boron Abundances in Early B Dwarfs of the Galactic Open Cluster NGC 3293

The Astrophysical Journal
New boron abundances or upper limits have been determined for eight early B stars in the young Galactic open cluster NGC 3293, using UV spectra obtained by the Hubble Space Telescope Cosmic Origins Spectrograph.
Charles R. Proffitt, Harim Jin, Simone Daflon, Daniel J. Lennon, Norbert Langer, Katia Cunha, Talawanda Monroe   +6 more
doaj   +1 more source