Results 91 to 100 of about 1,884 (262)

Boron Abundances in Early B Dwarfs of the Galactic Open Cluster NGC 3293

The Astrophysical Journal
New boron abundances or upper limits have been determined for eight early B stars in the young Galactic open cluster NGC 3293, using UV spectra obtained by the Hubble Space Telescope Cosmic Origins Spectrograph.
Charles R. Proffitt, Harim Jin, Simone Daflon, Daniel J. Lennon, Norbert Langer, Katia Cunha, Talawanda Monroe   +6 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Aeos Is Mixing It Up: The (In)homogeneity of Metal Mixing Following Population III Star Formation

The Astrophysical Journal
Stellar surface abundances are records of the state of the gas from which stars formed and thus trace how individual elements have mixed into the surrounding medium following their ejection from stars.
Jennifer Mead, Kaley Brauer, Greg L. Bryan, Mordecai-Mark Mac Low, Alexander P. Ji, John H. Wise, Eric P. Andersson, Anna Frebel, Andrew Emerick, Benoit Côté   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Inferring stellar metallicity and elemental abundances from kinematic and spectroscopic data using machine learning

Astronomy & Astrophysics
Context. Elemental abundances of FGK stars can be derived routinely from high-resolution optical spectra, but this remains considerably more difficult for cooler stars.
Adibekyan V., Soares B. M. T. B., Sousa S. G., Santos N. C., Delgado-Mena E., Minchev I., Chertovskih R., Martirosyan Zh., Israelian G., Hakobyan A. A.   +9 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Stellar Ancestry Unlocked: Chemical and Orbital Clues Link Metal-poor Stars to Globular Clusters and the Galaxy’s Thick Disk

The Astronomical Journal
This study presents a detailed chemical, kinematic, and orbital dynamic analysis of five metal-poor stars in the solar neighborhood: HD 2665, HD 5916, HD 122956, HD 189349, and HD 218857.
Gizay Yolalan, Timur Şahin, Selçuk Bilir, Olcay Plevne   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Metal-enriched Pair-instability Supernovae: Effects of Rotation

The Astrophysical Journal
In this paper, we revisit metal-enriched rotating pair-instability supernovae (PISNe) models for metallicities consistent with the Small Magellanic Cloud, the Large Magellanic Cloud (LMC), and 0.1 Z _⊙ .
Hideyuki Umeda, Chris Nagele
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source