Results 91 to 100 of about 63,862 (294)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Coronal Emission Measures and Abundances for Moderately Active K Dwarfs Observed by Chandra
, 2006 We have used Chandra to resolve the nearby 70 Oph (K0 V+K5 V) and 36 Oph (K1 V+K1 V) binary systems for the first time in X-rays. The LETG/HRC-S spectra of all four of these stars are presented and compared with an archival LETG spectrum of another ...
Arnaud M. +9 more
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
What Physical Factors Influence the Transformation between Blue Supergiants and Red Supergiants?
The Astrophysical JournalThe post-main-sequence evolution of massive stars is highly sensitive to key stellar model parameters, particularly initial rotational velocity and metallicity.
Yun He +8 more
doaj +1 more source
Fluorine in the solar neighborhood - is it all produced in AGB-stars?
, 2014 The origin of 'cosmic' fluorine is uncertain, but there are three proposed production sites/mechanisms: AGB stars, $\nu$ nucleosynthesis in Type II supernovae, and/or the winds of Wolf-Rayet stars.
Harper, G. M. +4 more
core +1 more source
Stellar Abundances: Better Measured Than Predicted [PDF]
Physics, 2013 The masses of exotic nuclei must be measured or calculated very precisely to explain how they led to the formation of heavy elements.
openaire +2 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The Impact of Initial Composition on Massive Star Evolution and Nucleosynthesis
The Astrophysical JournalWe study the sensitivity of presupernova evolution and supernova nucleosynthesis yields of massive stars to variations of the initial composition. We use the solar abundances from Lodders, and compute two different sets of initial stellar compositions ...
Christopher West +4 more
doaj +1 more source
Selecting a Photometric System for Gaia: C, N, O and Alpha-Process Elements
Open Astronomy, 2003 The sensitivity of stellar spectra to C, N, O and α-process element abundances is discussed with the aim of taking this effect into account when selecting a photometric system for the Gaia orbiting observatory.
Tautvaišienė G. +2 more
doaj +1 more source
Nucleosynthesis: Stellar and Solar Abundances and Atomic Data [PDF]
, 2006 Abundance observations indicate the presence of often surprisingly large amounts of neutron capture (i.e., s- and r-process) elements in old Galactic halo and globular cluster stars.
Collier, Jason +5 more
core +4 more sources