Results 91 to 100 of about 250,517 (293)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Stellar magnetism : empirical trends with age and rotation [PDF]

, 2014
AAV acknowledges support from a Royal Astronomical Society Fellowship and from the Swiss National Science Foundation via an Ambizione Fellowship. SGG acknowledges support from the Science and Technology Facilities Council (STFC) via an Ernest Rutherford ...
G. Hussain, Jeffers, S., Do Nascimento Jr., J.D., Waite, I.A., R. Fares, Folsom, C. P., Gregory, S. G.; id_orcid, P. Petit, Gregory, S. G., Hussain, G., do Nascimento, J. D., Donati, J. -F., Jardine, M., M. Jardine, Vidotto, A. A., Petit, P., I. A. Waite, Marsden, S., S. Marsden, Vidotto, A. A, Nascimento Júnior, José Dias do, Donati, J.F., J. Bouvier, J. Morin, J. D. Do Nascimento, Nascimento, J. D. Do, C. P. Folsom, Donati, J. F., Morin, J., Bouvier, J., J. F. Donati, Waite, I. A., Gregory, S.G., Jeffers, Sandra V., Fares, R., Hussain, G. A. J., Cameron, A. C., A. A. Vidotto, Morin, Julien, do Nascimento Jr., J.-D., A. C. Cameron, S. Jeffers, Cameron, A.C., S. G. Gregory, Vidotto, A.A., Folsom, C.P.   +45 more
core   +1 more source

A Systematic NLTE Study of Very Metal-poor Stars with Metallicity down to −4.3 dex. VI. Light Neutron-capture Elements and the Sr–Na Correlation as a Signature of Spinstar Nucleosynthesis in the Early Galaxy

The Astrophysical Journal
We present a non–local thermodynamic equilibrium (NLTE) abundance analysis of the light neutron-capture elements Sr, Y, and Zr in a sample of 103 very metal-poor stars spanning −4.3 ≲ [Fe/H] ≲ −1.7, based on high-resolution Subaru/HDS spectra and ...
Sofya Alexeeva, Hongliang Yan, Gang Zhao, Jianrong Shi, Haining Li, Shuai Liu, Zeming Zhou, Junbo Zhang, Jingkun Zhao, Yaqian Wu, Yuqin Chen, Huiling Chen, Huawei Zhang, Wako Aoki   +13 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Anchoring Stellar Age Indicators: A Cross Calibration of [C/N] and Gyrochronology Ages via the Age–Velocity Dispersion Relation

The Astronomical Journal
Determining stellar ages is challenging, as it depends on other stellar parameters in a nonlinear way and often relies on stellar evolution models to infer the underlying relation between these parameters and age. This complexity increases when comparing
Yuxi(Lucy) Lu, Marc H. Pinsonneault, Yuan-Sen Ting, Phil R. Van-Lane, John D. Roberts, Jamie Tayar, Alexander Stone-Martinez, Amanda L. Ash   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Abundance of Helium in Stellar Atmospheres [PDF]

Highlights of Astronomy, 1971
Helium abundance in stellar atmospheres has been the subject of several recent investigations, essentially induced by progresses in the computation of non-grey model atmospheres (including line blanketing in the far U.V.), by considerable advances in the theory of Stark broadening of helium lines, by non local thermodynamic equilibrium (LTE) work for ...
openaire   +1 more source

Abundances

, 2016
Species identities and relative abundances of each species on each sampling point of each ...
Oñate, Juan J., Morales, Manuel B., Juan J. Oñate (2907422), Carlos P. Carmona (3249810), Carmona, Carlos P., Irene Guerrero (2907395), Peco, Begoña, Guerrero, Irene, Manuel B. Morales (518439), Begoña Peco (487604)   +9 more
core   +1 more source

The Impact of Initial Composition on Massive Star Evolution and Nucleosynthesis

The Astrophysical Journal
We study the sensitivity of presupernova evolution and supernova nucleosynthesis yields of massive stars to variations of the initial composition. We use the solar abundances from Lodders, and compute two different sets of initial stellar compositions ...
Christopher West, Alexander Heger, Benoit Côté, Lev Serxner, Haoxuan Sun   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source