Results 81 to 90 of about 63,862 (294)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Fluorine Abundances in Local Stellar Populations

The Astronomical Journal
We present the first fluorine measurements in 12 normal K giants belonging to the Galactic thin and thick disks using spectra obtained with the Phoenix infrared spectrometer on the 2.1 m telescope at Kitt Peak. Abundances are determined from the (1−0) R9
K. E. Brady, C. A. Pilachowski, V. Grisoni, Z. G. Maas, K. A. Nault   +4 more
doaj   +1 more source

Inferring stellar compositions [PDF]

EPJ Web of Conferences
Stars are not hydrostatic spheres and their atmospheric layers are not in local thermodynamic equilibrium. Inferring stellar surface abundances from such 1D+LTE models is subject to significant biases.
Korn Andreas J.
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Anchoring Stellar Age Indicators: A Cross Calibration of [C/N] and Gyrochronology Ages via the Age–Velocity Dispersion Relation

The Astronomical Journal
Determining stellar ages is challenging, as it depends on other stellar parameters in a nonlinear way and often relies on stellar evolution models to infer the underlying relation between these parameters and age. This complexity increases when comparing
Yuxi(Lucy) Lu, Marc H. Pinsonneault, Yuan-Sen Ting, Phil R. Van-Lane, John D. Roberts, Jamie Tayar, Alexander Stone-Martinez, Amanda L. Ash   +7 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A Systematic NLTE Study of Very Metal-poor Stars with Metallicity down to −4.3 dex. VI. Light Neutron-capture Elements and the Sr–Na Correlation as a Signature of Spinstar Nucleosynthesis in the Early Galaxy

The Astrophysical Journal
We present a non–local thermodynamic equilibrium (NLTE) abundance analysis of the light neutron-capture elements Sr, Y, and Zr in a sample of 103 very metal-poor stars spanning −4.3 ≲ [Fe/H] ≲ −1.7, based on high-resolution Subaru/HDS spectra and ...
Sofya Alexeeva, Hongliang Yan, Gang Zhao, Jianrong Shi, Haining Li, Shuai Liu, Zeming Zhou, Junbo Zhang, Jingkun Zhao, Yaqian Wu, Yuqin Chen, Huiling Chen, Huawei Zhang, Wako Aoki   +13 more
doaj   +1 more source

Oxygen and silicon abundances in Cygnus OB2: Chemical homogeneity in a sample of OB slow rotators

, 2018
Cygnus OB2 is a rich OB association in the Galaxy which has experienced intense star formation in the last 20-25 Myr. Its stellar population shows a correlation between age and Galactic longitude. Exploring the chemical composition of its stellar content
Berlanas, S. R., Cerviño, M., Comerón, F., Herrero, A., Pasquali, A., Simón-Díaz, S.   +5 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Primordial Lithium from Globular Cluster Turnoff Stars: M13 and M71

The Astrophysical Journal
During Big Bang nucleosynthesis (BBN) in the first 15 minutes of the Universe, some ^7 Li was created along with isotopes of H and He. The determination of that primordial value of Li can help constrain the conditions at that time.
Ann Merchant Boesgaard, Constantine P. Deliyannis   +1 more
doaj   +1 more source