Results 101 to 110 of about 992,258 (306)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

NGC 1856: Using Machine Learning Techniques to Uncover Detailed Stellar Abundances from MUSE Data

The Astronomical Journal
We present the first application of the novel approach based on data-driven machine learning methods applied to Multi-Unit Spectroscopic Explorer (MUSE) field data to derive stellar abundances of star clusters.
Randa Asa’d, S. Hernandez, J. M John, M. Alfaro-Cuello, Z. Wang, A. As’ad, A. Vasini, F. Matteucci   +7 more
doaj   +1 more source

THE RAVE CATALOG OF STELLAR ELEMENTAL ABUNDANCES: FIRST DATA RELEASE [PDF]

The Astronomical Journal, 2011
We present chemical elemental abundances for $36,561$ stars observed by the RAdial Velocity Experiment (RAVE), an ambitious spectroscopic survey of our Galaxy at Galactic latitudes $|$b$|>25^{\circ}$ and with magnitudes in the range 9$
Zwitter, Tomaž, Ruchti, Gregory R., Bienaymé, Olivier, Bland-Hawthorn, Joss Bland, Campbell, Randy D., Freeman, Kenneth C., Gibson, Brad K., Gilmore, Gerard F., Boeche, Corrado, Siebert, Arnaud, Williams, Mary E K, De Jong, Roelof S., Steinmetz, Matthias, Fulbright, Jon P., Grebel, Eva K., Helmi, Amina, Munari, Ulisse, Navarro, Julio F., Parker, Quentin A., Reid, Warren A., Seabroke, George M., Siviero, Alessandro, Watson, Fred G., Wyse, Rosemary F G   +23 more
openaire   +6 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Stellar abundances and ages for metal-rich Milky Way globular clusters - Stellar parameters and el [PDF]

, 2008
Context. Metal-rich globular clusters provide important tracers of the formation of our Galaxy. Moreover, and not less important, they are very important calibrators for the derivation of properties of extra-galactic metal-rich stellar populations ...
S. Feltzing, F. Primas, R. A. Johnson
semanticscholar   +1 more source

Stellar Production Rates of Carbon and Its Abundance in the Universe [PDF]

Science, 2000
The bulk of the carbon in our universe is produced in the triple-alpha process in helium-burning red giant stars. We calculated the change of the triple-alpha reaction rate in a microscopic 12-nucleon model of the 12 C nucleus and looked for the effects of minimal variations of the strengths of the underlying ...
Oberhummer, Heinz, Csoto, Attila, Schlattl, Helmut   +2 more
openaire   +3 more sources

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Fluorine Abundances in Local Stellar Populations

The Astronomical Journal
We present the first fluorine measurements in 12 normal K giants belonging to the Galactic thin and thick disks using spectra obtained with the Phoenix infrared spectrometer on the 2.1 m telescope at Kitt Peak. Abundances are determined from the (1−0) R9
K. E. Brady, C. A. Pilachowski, V. Grisoni, Z. G. Maas, K. A. Nault   +4 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source