Results 121 to 130 of about 250,517 (293)

Tracing kinematic (mis)alignments in CALIFA merging galaxies : Stellar and ionized gas kinematic orientations at every merger stage [PDF]

, 2015
J.M.A. and V.W. acknowledge support from the European Research Council Starting Grant (SEDmorph; P.I. V. Wild).We present spatially resolved stellar and/or ionized gas kinematic properties for a sample of 103 interacting galaxies, tracing all merger ...
Ziegler, Katharina B., Bekeraitė, S., D. Mast, Verdes-Montenegro, L., Mcintosh, D., Monreal-Ibero, A., González Delgado, R. M., Aguerri, J., Sánchez, S. F., Lyubenova, M., Kehrig, C., J. Falcón-Barroso, Vílchez, J., Sanchez, Sébastien, García-Benito, R., D. H. McIntosh, J. K. Barrera-Ballesteros, G. van de Ven, Ziegler, B., del Olmo, A., Wild, V., González Delgado, R., Barrera-Ballesteros, J., B. García-Lorenzo, R. García-Benito, García-Lorenzo, B., Méndez-Abreu, J., V. Wild, Cortijo-Ferrero, C., Bomans, D. J., J. Méndez-Abreu, A. Monreal-Ibero, B. Husemann, Iglesias-Paramo, J., Marquez, I., Mast, Damian, Bland-Hawthorn, J., L. Verdes-Montenegro, van de Ven, G., Marino, R. A., R. M. González Delgado, C. J. Walcher, M. Lyubenova, A. del Olmo, Mast, D., I. Marquez, S. Bekeraitė, McIntosh, D. H., Husemann, B., Barrera-Ballesteros, J.K., Aguerri, J. A. L., J. A. L. Aguerri, Barrera-Ballesteros, J. K., Marino, R., J. M. Vílchez, J. Iglesias-Paramo, Marino, R.A., D. J. Bomans, J. Bland-Hawthorn, Walcher, C. J., McIntosh, D.H., R. A. Marino, B. Ziegler, Walcher, C., S. F. Sánchez, Bomans, D., C. Kehrig, Vílchez, J. M., J. Masegosa, Falcón-Barroso, J., Masegosa, J., C. Cortijo-Ferrero   +71 more
core   +2 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Metal-enriched Pair-instability Supernovae: Effects of Rotation

The Astrophysical Journal
In this paper, we revisit metal-enriched rotating pair-instability supernovae (PISNe) models for metallicities consistent with the Small Magellanic Cloud, the Large Magellanic Cloud (LMC), and 0.1 Z _⊙ .
Hideyuki Umeda, Chris Nagele
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Stellar Ancestry Unlocked: Chemical and Orbital Clues Link Metal-poor Stars to Globular Clusters and the Galaxy’s Thick Disk

The Astronomical Journal
This study presents a detailed chemical, kinematic, and orbital dynamic analysis of five metal-poor stars in the solar neighborhood: HD 2665, HD 5916, HD 122956, HD 189349, and HD 218857.
Gizay Yolalan, Timur Şahin, Selçuk Bilir, Olcay Plevne   +3 more
doaj   +1 more source

Inferring stellar metallicity and elemental abundances from kinematic and spectroscopic data using machine learning

Astronomy & Astrophysics
Context. Elemental abundances of FGK stars can be derived routinely from high-resolution optical spectra, but this remains considerably more difficult for cooler stars.
Adibekyan V., Soares B. M. T. B., Sousa S. G., Santos N. C., Delgado-Mena E., Minchev I., Chertovskih R., Martirosyan Zh., Israelian G., Hakobyan A. A.   +9 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

SP_Ace: a new code to derive stellar parameters and elemental abundances

, 2016
Context. Ongoing and future massive spectroscopic surveys will collect large numbers (106–107) of stellar spectra that need to be analyzed. Highly automated software is needed to derive stellar parameters and chemical abundances from these spectra.
E. K. Grebel, C. Boeche
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source