Results 111 to 120 of about 1,884 (262)

Calibration of the [C/N] and [Y/Mg] chemical clocks with asteroseismic ages from the TESS space mission

Astronomy & Astrophysics
Context. Stellar ages are typically very difficult to estimate for field stars. New empirical methods, based on abundance ratios of chemical elements, are emerging and need to be calibrated. Aims.
Pakštienė E., Tautvaišienė G., Bagdonas V., Kjeldsen H., Winther M. L., Drazdauskas A., Viscasillas Vázquez C., Chorniy Y., Mikolaitis Š., Minkevičiūte R., Stonkutė E.   +10 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Abundance Measurements of the Metal-poor M Subdwarf LHS 174 Using High-resolution Optical Spectroscopy

The Astronomical Journal
Metal-poor M subdwarfs are among the oldest stellar populations and carry valuable information about the chemical enrichment history of the Milky Way. The measurements of chemical abundances of these stars therefore provide essential insights into the ...
Neda Hejazi, Sébastien Lépine, Thomas Nordlander, Wei-Chun Jao, David R. Coria, Kathryn V. Lester   +5 more
doaj   +1 more source

Super-Earth masses and stellar abundances from NIRPS reveal tentative evidence for water-rich formation around M dwarfs

Astronomy & Astrophysics
Tracing the compositional link between terrestrial super-Earths and their host stars provides clues about their dominant formation pathway. By constraining the stellar abundances of refractory elements, we can predict the core mass fractions (CMFs) of ...
Weisserman Drew, Gromek Nicole, Cloutier Ryan, Bali Komal, Cadieux Charles, Plotnykov Mykhaylo, L’Heureux Alexandrine, Srivastava Avidaan, Carmona Andres, Frensch Yolanda G. C., Artigau Étienne, Baron Frédérique, Barros Susana C. C., Benneke Björn, Bonfils Xavier, Bouchy François, Bryan Marta, Cook Neil J., Cowan Nicolas B., Cristo Eduardo, Delfosse Xavier, Doyon René, Dumusque Xavier, Ehrenreich David, González Hernández Jonay I., Lafrenière David, de Castro Leão Izan, Lovis Christophe, Malo Lison, Canto Martins Bruno L., Suárez Mascareño Alejandro, De Medeiros Jose Renan, Melo Claudio, Mignon Lucile, Mordasini Christoph, Pepe Francesco, Rebolo Rafael, Rowe Jason, Santos Nuno C., Ségransan Damien, Udry Stéphane, Valencia Diana, Wade Gregg, Aguiar José Luan A., Allart Romain, Bazinet Luc, Delisle Jean-Baptiste, Bélanger Flavie, Blackman Joshua, Bourrier Vincent, Branco Pedro, Bruniquel Vincent, Carteret Yann, Cointepas Marion, Darveau-Bernier Antoine, Dauplaise Laurie, Delgado-Mena Elisa, Dorn Caroline, Doshi Dhvani, Faria João, Fontinele Dasaev O., Forveille Thierry, Gagné Jonathan, Genest Frédéric, Glover Jennifer, de Lima Gomes Roseane, Grieves Nolan, Hobson Melissa J., Hoeijmakers H. Jens, Jahandar Farbod, Krishnamurthy Vigneshwaran, Lamontagne Pierrot, Larue Pierre, Leath Henry, Lim Olivia, Lipper Justin, Messamah Lina, Messias Yuri S., Monteiro Telmo, Moranta Leslie, Al Moulla Khaled, Mounzer Dany, Mraz Georgia, Nari Nicola, Nielsen Louise D., Osborn Ares, Otegi Jon, Parc Léna, Pelletier Stefan, Pereira Olivia, Piaulet-Ghorayeb Caroline, Rosener Riley, Seidel Julia, Gomes da Silva João, Costa Silva Ana Rita, Stefanov Atanas K., Teixeira Márcio A., Vandal Thomas, Vaulato Valentina, Wardenier Joost P., Yariv Vincent   +100 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

PhDLspec: Physical Prior Embedded Deep Learning Method for Spectroscopic Determination of Stellar Labels in High-dimensional Parameter Space

The Astrophysical Journal
Unlocking all the physical information encoded in low-resolution spectra poses a significant challenge for astronomical survey analysis. Such a task demands modeling spectra and optimizing astrophysical parameters in high-dimensional space as a ...
Tianmin Wu, Maosheng Xiang, Jianrong Shi, Meng Zhang, Lanya Mou, Hong-Liang Yan, A-Li Luo   +6 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Chemical Cartography with APOGEE: Two-process Parameters and Residual Abundances for 288,789 Stars from Data Release 17

The Astrophysical Journal
Stellar abundance measurements are subject to systematic errors that induce extra scatter and artificial correlations in elemental abundance patterns. We derive empirical calibration offsets to remove systematic trends with surface gravity $\mathrm{log ...
Tawny Sit, David H. Weinberg, Adam Wheeler, Christian R. Hayes, Sten Hasselquist, Thomas Masseron, Jennifer Sobeck   +6 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

JWST Exoplanetary Worlds and Elemental Survey (JEWELS). II. Condensation Temperature Trends and Galactic Chemical Evolution in JWST Planet-hosting Stars

The Astrophysical Journal Supplement Series
We present high-precision chemical abundances for 25 FGK-type stars hosting exoplanets observed in JWST Cycle 3 programs and all Guaranteed Time Observations and Director’s Discretionary Time programs from Cycles 1–3, based on high-resolution, high ...
Qinghui Sun, Xianyu Tan, Gordon (Kai Hou) Yip, Zitao Lin, Fan Liu, Sharon Xuesong Wang, Zhengduo Li   +6 more
doaj   +1 more source