Results 111 to 120 of about 63,862 (294)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The Astrophysical JournalWe present a quantitative spectroscopic study of 13 blue supergiant stars in the Pinwheel Galaxy M101, based on data obtained with the Low Resolution Imaging Spectrometer available at the Keck I telescope.
Fabio Bresolin +4 more
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
The Astronomical JournalThe era of JWST has enabled measurements of abundances of elements such as C, O, and even Na, S, K, and Fe in planetary atmospheres to very high precisions (∼0.1 dex).
Aneesh Baburaj +4 more
doaj +1 more source
Lithium abundances in globular cluster giants: NGC 6218 (M12) and NGC 5904 (M5)
, 2014 Convergent lines of evidence suggest that globular clusters host multiple stellar populations. It appears that they experience at least two episodes of star formation whereby a fraction of first-generation stars contribute astrated ejecta to form the ...
Angelou, George C. +7 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Boron Abundances in Early B Dwarfs of the Galactic Open Cluster NGC 3293
The Astrophysical JournalNew boron abundances or upper limits have been determined for eight early B stars in the young Galactic open cluster NGC 3293, using UV spectra obtained by the Hubble Space Telescope Cosmic Origins Spectrograph.
Charles R. Proffitt +6 more
doaj +1 more source
Stellar Abundances in Dwarf Irregular Galaxies
, 2003 Dwarf irregular galaxies appear to have undergone very slow chemical evolution since they have low nebular abundances, but have had ongoing star formation over the past 15 Gyr. They are too distant for red giant abundance analyses to examine the details of their chemical evolution, however the isolated, bright blue supergiants do allow us to determine ...
Venn, K.A. +3 more
openaire +3 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Aeos Is Mixing It Up: The (In)homogeneity of Metal Mixing Following Population III Star Formation
The Astrophysical JournalStellar surface abundances are records of the state of the gas from which stars formed and thus trace how individual elements have mixed into the surrounding medium following their ejection from stars.
Jennifer Mead +9 more
doaj +1 more source