Results 91 to 100 of about 7,344 (264)
The Astronomical JournalThe Closeby Habitable Exoplanet Survey (CHES) is dedicated to the astrometric exploration for habitable-zone Earth-like planets orbiting solar-type stars in close proximity, achieving unprecedented microarcsecond precision.
Chunhui Bao +6 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Molecular Hydrogen Controls the Temperatures of Flares on TRAPPIST-1
The Astrophysical Journal LettersEarly JWST observations of TRAPPIST-1 have revealed an unexpected puzzle: energetic white-light flares ( E > 10 ^30 erg) reach temperatures of only ∼3500–4000 K, nearly 3 times cooler than typical solar flares, which peak around 9000–10,000 K.
A. I. Shapiro +9 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source
Solar and stellar activity cycles
Journal of Physics: Conference Series, 2008 A variety of different dynamo models have been proposed for the Sun. While the basic ingredients of the solar dynamo are known, there is no general agreement about the combination and the relative importance of these basic processes. Unfortunately observational constraints are not strong enough to clearly distinguish between different dynamo models ...
openaire +2 more sources
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
35 pages, 10 figures, 1 table, to be published as a chapter in 'Space Environments and their Impact on Exoplanets', editor O ...
Bellotti, S., Morin, J.
openaire +2 more sources