Results 191 to 200 of about 7,344 (264)

Long-term Doppler imaging of the star XX Trianguli indicates chaotic non-periodic dynamo. [PDF]

Nat Commun
Strassmeier KG, Kővári Z, Weber M, Granzer T.   +3 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Helioseismic evidence that the solar dynamo originates near the tachocline. [PDF]

Sci Rep
Mandal K, Kosovichev AG.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Neutron capture measurements for s-process nucleosynthesis: A review about CERN n_TOF developments and contributions. [PDF]

Eur Phys J A Hadron Nucl
Domingo-Pardo C, Aberle O, Alcayne V, Alpar G, Halabi MA, Amaducci S, Babiano V, Bacak M, Balibrea-Correa J, Bartolomé J, Bernardes AP, Gameiro BB, Berthoumieux E, Beyer R, Birch M, Boromiza M, Bosnar D, Brusasco B, Caamaño M, Cahuzac A, Calviño F, Calviani M, Cano-Ott D, Casanovas A, Castelluccio DM, Catlett D, Cerutti F, Cescutti G, Chiaveri E, Claps G, Colombetti P, Colonna N, Camprini PC, Cortés G, Cortés-Giraldo MA, Cosentino L, Cristallo S, D'Ottavi A, de la Fuente Rosales G, Dellmann SF, Diakaki M, Di Castro M, Di Chicco A, Dietz M, Dupont E, Durán I, Eleme Z, Eslami M, Fargier S, Fernández-Domínguez B, Finocchiaro P, Flanagan W, Furman V, Gandhi A, García-Infantes F, Gawlik-Ramiega A, Gervino G, Gilardoni S, González-Romero E, Goula S, Griesmayer E, Guerrero C, Gunsing F, Gustavino C, Heyse J, Hillman W, Jenkins DG, Jericha E, Junghans A, Kadi Y, Kaperoni K, Kelly I, Kokkoris M, Kopatch Y, Krtička M, Kyritsis N, Lederer-Woods C, Lerendegui-Marco J, Manna A, Martínez T, Martínez-Cañada M, Masi A, Massimi C, Mastinu P, Mastromarco M, Maugeri EA, Mazzone A, Mendoza E, Mengoni A, Michalopoulou V, Milazzo PM, Moldenhauer J, Mucciola R, González EM, Musumarra A, Negret A, Odusina E, Papanikolaou D, Patronis N, Pavón-Rodríguez JA, Pellegriti MG, Pérez-Maroto P, de Rada Fiol AP, Perfetto G, Perkowski J, Petrone C, Pieretti N, Piersanti L, Pirovano E, Porras I, Praena J, Quesada JM, Reifarth R, Rochman D, Romanets Y, Rooney A, Rovira G, Rubbia C, Sánchez-Caballero A, Sahoo RN, Scarpa D, Schillebeeckx P, Smith AG, Sosnin NV, Spelta M, Stamati ME, Stasiak K, Tagliente G, Tarifeño-Saldivia A, Tarrío D, Torres-Sánchez P, Tosi S, Tsiledakis G, Valenta S, Vaz P, Vecchio G, Vescovi D, Vlachoudis V, Vlastou R, Wallner A, Weiss C, Woods PJ, Wright T, Wu R, Žugec P, The n_TOF Collaboration.   +145 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Immune Modulation in Cancer: The Role of Tumor-Treating Fields (TTFields). [PDF]

Curr Protoc
Liu M, Hage ME, Zhao J, Linnebacher M.
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Intensities of the hydrogen Balmer lines of solar-like stars revealed by the LAMOST spectroscopic surveys. [PDF]

Sci Rep
He H.
europepmc   +1 more source