Results 71 to 80 of about 7,344 (264)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

TESS Asteroseismology of β Hydri: A Subgiant with a Born-again Dynamo

open access: yesThe Astrophysical Journal
The solar-type subgiant β Hyi has long been studied as an old analog of the Sun. Although the rotation period has never been measured directly, it was estimated to be near 27 days.
Travis S. Metcalfe   +14 more
doaj   +1 more source

Seismological insights into solar and stellar magnetic activity cycles

open access: yesEPJ Web of Conferences, 2017
The Sun’s magnetic activity cycle varies primarily on a time scale of approximately 11yrs from minimum to maximum and back again. It is well-known that the properties of the Sun’s acoustic oscillations are affected by the near-surface internal magnetic ...
Broomhall Anne-Marie
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Relations of Rotation and Chromospheric Activity to Stellar Age for FGK Dwarfs from Kepler and LAMOST

open access: yesThe Astrophysical Journal Supplement Series
The empirical relations between rotation period, chromospheric activity, and age can be used to estimate stellar age. To calibrate these relations, we present a catalog, including the masses and ages of 52,321 FGK dwarfs, 47,489 chromospheric activity ...
Lifei Ye   +11 more
doaj   +1 more source

Stellar magnetic activity – Star-Planet Interactions

open access: yesEPJ Web of Conferences, 2015
Stellar magnetic activity is an important factor in the formation and evolution of exoplanets. Magnetic phenomena like stellar flares, coronal mass ejections, and high-energy emission affect the exoplanetary atmosphere and its mass loss over time.
Poppenhaeger, K.
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

The California Legacy Survey. VI. The Fate of Activity Cycles in Sun-like Stars

open access: yesThe Astronomical Journal
We analyze the spectra of 91 solar-type G- and K-type main-sequence dwarfs in the solar neighborhood to assess activity trends with stellar properties.
Howard Isaacson   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Starspot Area Coverage: Correlation with Age and Spectral Type in FGK and M Stars

open access: yesThe Astrophysical Journal Letters
Starspots, analogous to sunspots, are surface manifestations of stellar magnetic activity. Their study provides crucial insights into stellar dynamo processes and the evolution of magnetic phenomena.
Alexandre Araújo   +3 more
doaj   +1 more source

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