Results 101 to 110 of about 95,404 (302)

The impact of systematic uncertainties in stellar parameters on integrated spectra of stellar populations

open access: yes, 2009
In this paper we investigate a hitherto unexplored source of potentially significant error in stellar population synthesis (SPS) models, caused by systematic uncertainties associated with the three fundamental stellar atmospheric parameters; effective ...
Alonso   +16 more
core   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

Benchmark ages for the Gaia benchmark stars

open access: yes, 2018
In the era of large-scale surveys of stars in the Milky Way, stellar ages are crucial for studying the evolution of the Galaxy. But determining ages of field stars is notoriously difficult; therefore, we attempt to determine benchmark ages for the ...
Church, Ross P.   +3 more
core   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

Stellar haloes of disc galaxies at z~1

open access: yes, 2013
Taking advantage of the ultra-deep near-infrared imaging obtained with the Hubble Space Telescope on the Hubble Ultra Deep Field, we detect and explore for the first time the properties of the stellar haloes of two Milky Way-like galaxies at z~1. We find
Abadi   +62 more
core   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

The Radiative–Convective Gap: Fact or Fiction?

open access: yesThe Astronomical Journal
Gaia characterizes the stellar populations of nearby open clusters with unprecedented precision. We investigate the Böhm-Vitense gap, which has been found as a prominent feature in the stellar sequence of open clusters. Using PARSEC isochrone fitting, we
Wolfgang Brandner   +3 more
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

Home - About - Disclaimer - Privacy