Results 111 to 120 of about 2,085 (265)
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
The Radiative–Convective Gap: Fact or Fiction?
Gaia characterizes the stellar populations of nearby open clusters with unprecedented precision. We investigate the Böhm-Vitense gap, which has been found as a prominent feature in the stellar sequence of open clusters. Using PARSEC isochrone fitting, we
Wolfgang Brandner +3 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Evolution of the Lithium–Rotation Correlation in Open Cluster F Dwarfs and a New Age Indicator
The Lithium Dip is a severe nonstandard depletion of surface Li in F dwarfs that occurs during the main sequence. We present Li and $v\sin i$ measurements from WIYN/Hydra and CTIO/Hydra spectra of four open clusters whose ages span the range between that
Aaron Steinhauer +1 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
The stellar initial mass function (IMF) is a key parameter to understand the star formation process and the integrated properties of stellar populations in remote galaxies.
Jae-Rim Koo, Hyun-Jeong Kim, Beomdu Lim
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
X-Ray Emission and Stellar Ages of Sun-like Stars
We present an analysis of XMM-Newton and Chandra observations of 85 nearby main-sequence FGK stars with age estimates ranging from 0.2 to 12 Gyr. We measure quiescent 0.3–10 keV luminosities, variability metrics, and multitemperature thermal plasma ...
Breanna A. Binder +6 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source

