Results 141 to 150 of about 96,030 (294)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Radiative–Convective Gap: Fact or Fiction?
The Astronomical JournalGaia characterizes the stellar populations of nearby open clusters with unprecedented precision. We investigate the Böhm-Vitense gap, which has been found as a prominent feature in the stellar sequence of open clusters. Using PARSEC isochrone fitting, we
Wolfgang Brandner +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Evolution of the Lithium–Rotation Correlation in Open Cluster F Dwarfs and a New Age Indicator
The Astrophysical Journal LettersThe Lithium Dip is a severe nonstandard depletion of surface Li in F dwarfs that occurs during the main sequence. We present Li and $v\sin i$ measurements from WIYN/Hydra and CTIO/Hydra spectra of four open clusters whose ages span the range between that
Aaron Steinhauer +1 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Model Choice Matters for Age Inference on the Red Giant Branch
The Astrophysical JournalGalactic archaeology relies on accurate stellar parameters to reconstruct the Galaxy's history, including information on stellar ages. While the precision of data has improved significantly in recent years, stellar models used for age inference have not ...
Leslie M. Morales +2 more
doaj +1 more source
FFNN–TabNet: An Enhanced Stellar Age Determination Method Based on TabNet
Applied SciencesThe precise ascertainment of stellar ages is pivotal for astrophysical research into stellar characteristics and galactic dynamics. To address the prevalent challenges of suboptimal accuracy in stellar age determination and limited proficiency in ...
Han Zhang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
The Astrophysical JournalWithin the molecular clouds of the Camelopardis OB1 (Cam OB1) association exists a region previously noted as one subgroup. However, bulk clustering from Gaia astrometry has recently shown three distinctive kinematically coherent groups, all found in a ...
Joseph Mullen +5 more
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source