Results 141 to 150 of about 7,481 (302)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Quantifying the stellar ages of dynamically separated bulges and disks of CALIFA spiral galaxies

We employ a recently developed population-orbit superposition technique to simultaneously fit the stellar kinematic and age maps of 82 CALIFA spiral galaxies and obtain the ages of stars in different dynamical structures.
Stefano Zibetti, Luca Costantin, Ling Zhu, Shude Mao, Yunpeng Jin, Glenn van de Ven   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Stellar coronae and chromospheres in the era of asteroseismology

, 2018
Stellar magnetic activity is an important parameter to study as it can give insights into stellar activity cycles and even how the stellar dynamo operates.
Wolk, S. J. (5621990), Watson, C. A., Stello, D. (5621987), Booth, R. S., Silva Aguirre, V., Poppenhaeger, K., Watson, C. A. (5621981), Stello, D., Poppenhaeger, K. (5621978), Wolk, S. J., Booth, R. S. (5621975), Silva Aguirre, V. (5621984)   +11 more
core   +1 more source

JADES + JEMS: A Detailed Look at the Buildup of Central Stellar Cores and Suppression of Star Formation in Galaxies at Redshifts 3 < z < 4.5

The Astrophysical Journal
We present a spatially resolved study of stellar populations in six galaxies with stellar masses M _* ∼ 10 ^10 M _☉ at z ∼ 3.7 using 14-filter James Webb Space Telescope (JWST)/NIRCam imaging from the JADES and JEMS surveys. The six galaxies are visually
Zhiyuan Ji, Christina C. Williams, Sandro Tacchella, Katherine A. Suess, William M. Baker, Stacey Alberts, Andrew J. Bunker, Benjamin D. Johnson, Brant Robertson, Fengwu Sun, Daniel J. Eisenstein, Marcia Rieke, Michael V. Maseda, Kevin Hainline, Ryan Hausen, George Rieke, Christopher N. A. Willmer, Eiichi Egami, Irene Shivaei, Stefano Carniani, Stephane Charlot, Jacopo Chevallard, Emma Curtis-Lake, Tobias J. Looser, Roberto Maiolino, Chris Willott, Zuyi Chen, Jakob M. Helton, Jianwei Lyu, Erica Nelson, Rachana Bhatawdekar, Kristan Boyett, Lester Sandles   +32 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Rotating Stellar Models Can Account for the Extended Main-sequence Turnoffs in Intermediate-age Clusters

, 2015
We show that the extended main-sequence turnoffs seen in intermediate-age Large Magellanic Cloud (LMC) clusters, often attributed to age spreads of several 100 Myr, may be easily accounted for by variable stellar rotation in a coeval population.
Huang, Chelsea X., Brandt, Timothy D.
core   +1 more source

Asteroseismically Inferred Ages of 132,000 Red Giants with TESS

The Astrophysical Journal Supplement Series
NASA’s Transiting Exoplanet Survey Satellite mission has identified at least 158,000 oscillating red giants, increasing the known sample by roughly an order of magnitude.
Artemis Theano Theodoridis, Leslie Morales, Jamie Tayar   +2 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

WINGS-SPE II: A catalog of stellar ages and star formation histories, stellar masses and dust extinction values for local clusters galaxies

, 2011
Context. The WIde-field Nearby Galaxy clusters Survey (wings) is a project whose primary goal is to study the galaxy populations in clusters in the local universe (z < 0.07) and of the influence of environment on their stellar populations.
A. Omizzolo (18997682), T. Valentinuzzi (18997706), A. Moretti (7604945), D. Bettoni (18997694), G. Fasano (18997679), J. Varela (18997691), A. Bressan (7599971), J. Fritz (4032521), P. Kjærgaard (18997688), A. Cava (7601567), M. D'Onofrio (17196184), M. Moles (7620842), A. Dressler (18997685), Warrick Couch (18925639), B. M. Poggianti (18997703)   +14 more
core   +1 more source