Results 131 to 140 of about 1,216,320 (294)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The Age Distribution of Stellar Orbit Space Clumps
The Astrophysical JournalThe orbit distribution of young stars in the Galactic disk is highly structured, from well-defined clusters to streams of stars that may be widely dispersed across the sky, but are compact in orbital action-angle space.
Verena Fürnkranz +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Solar and stellar rotation [PDF]
, 2007 Workshop on Solar and Stellar Physics through Eclipses -- MAR 27-29, 2006 -- Ankara Univ, ORSEM Campus, Side, Antalya, TURKEYThe secular evolution of the stellar rotation through angular momentum loss, driven by the stellar wind, and the consequences of ...
Demircan, O., Filiz-Ak, N., Eker, Z.
core
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
The Mass of the Vela Pulsar Progenitor and the Age of the Vela-Puppis Complex
The Astrophysical JournalThe association of the Vela Pulsar with the Vela Supernova Remnant has long supported the hypothesis that core-collapse supernovae yield neutron stars, but its surrounding stellar population now offers new insights into progenitor evolution.
Jeremiah W. Murphy +6 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
PAH Feature Ratios around Stellar Clusters and Associations in 19 Nearby Galaxies
The Astronomical JournalWe present a comparison of observed polycyclic aromatic hydrocarbon (PAH) feature ratios in 19 nearby galaxies with a grid of theoretical expectations for near- and mid-infrared dust emission.
Daniel A. Dale +29 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source