Results 141 to 150 of about 40,509 (299)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
A Multimethod Age Determination for the Ursa Major Moving Group
The Astronomical JournalThe Ursa Major Moving Group (UMa) is one of the closest stellar associations, yet its age has remained controversial, with published estimates ranging from 200 Myr to 1 Gyr.
Julia Sheffler +6 more
doaj +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
The Emerging Stellar Complex in Mon R2: Membership and Optical Variability Classification
The Astronomical JournalMonoceros R2 (Mon R2) is one of the closest large active star-forming regions. This extremely young and partially embedded region provides an excellent laboratory for studying star formation and the early evolution of young stellar objects (YSOs).
Sally D. Jiang, Lynne A. Hillenbrand
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
The Astronomical JournalSupergiant shells (SGSs) are the largest interstellar structures where heated and enriched gas flows into the host galaxy’s halo. The SGSs in the Large Magellanic Cloud (LMC) are so close that their stars can be resolved with ground-based telescopes to ...
Po-Sheng Ou +4 more
doaj +1 more source
Integration of deep learning-based histopathology and transcriptomics reveals key genes associated with fibrogenesis in patients with advanced NASH. [PDF]
Cell Rep Med, 2023 Conway J +14 more
europepmc +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Evolution of Flare Activity in GKM Stars Younger Than 300 Myr over Five Years of TESS Observations
The Astronomical JournalStellar flares are short-duration (< hours) bursts of radiation associated with surface magnetic reconnection events. Stellar magnetic activity generally decreases as a function of both the age and Rossby number, R _0 , a measure of the relative ...
Adina D. Feinstein +4 more
doaj +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source