Results 161 to 170 of about 41,072 (339)

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Discovery of the Remarkably Red L/T Transition Object VHS J183135.58-551355.9

The Astronomical Journal
We present the discovery of VHS J183135.58−551355.9 (hereafter VHS J1831−5513), an L/T transition dwarf identified as a result of its unusually red near-infrared colors ( J − K _S = 3.633 ± 0.277 mag; J − W 2 = 6.249 ± 0.245 mag) from the VISTA ...
Thomas P. Bickle, Adam C. Schneider, Jonathan Gagné, Jacqueline K. Faherty, Austin Rothermich, Johanna M. Vos, Genaro Suárez, J. Davy Kirkpatrick, Aaron M. Meisner, Marc J. Kuchner, Adam J. Burgasser, Federico Marocco, Sarah L. Casewell, Dan Caselden, Daniella C. Bardalez Gagliuffi, The Backyard Worlds: Planet 9 Collaboration   +15 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

TESS Hunt for Young and Maturing Exoplanets (THYME). XIV. A Comoving-based Age Constraint for KELT-20

The Astronomical Journal
Young stellar moving groups offer unique opportunities to investigate the early evolution of stellar and planetary systems. In continuation of an ongoing effort to age-date compelling planetary systems, we provide an in-depth age analysis of KELT-20—a ...
Adam Distler, Melinda Soares-Furtado, Andrew W. Mann, Adam L. Kraus, Jonathan Gagné, Juliette Becker, Ritvik Sai Narayan, Max Clark, Andrew Vanderburg, Joseph E. Rodriguez, Laura K. Rogers, Ronan Kerr   +11 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

The massive stellar population in the young association LH 95 in the Large Magellanic Cloud [PDF]

, 2012
N. Da Rio, D. A. Gouliermis, B. Rochau, A. Pasquali, J. Setiawan, G. De Marchi   +5 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Stellar Associations in the Tail of NGC 4038 [PDF]

, 2004
I. Saviane, J. E. Hibbard, R. Michael Rich   +2 more
openalex   +1 more source

The kinematics of young stellar population in the W5 region of the Cassiopeia OB6 association: implication on the formation process of stellar associations [PDF]

, 2023
Beomdu Lim, Jongsuk Hong, Jinhee Lee, Hyeong-Sik Yun, Narae Hwang, Byeong-Gon Park   +5 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source