Results 41 to 50 of about 309 (219)
Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain
Advanced Science, EarlyView.This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao +7 more
wiley +1 more source
Advanced Science, EarlyView.A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Jiantao Zhao +14 more
wiley +1 more source
Probing the Low-velocity Regime of Nonradiative Shocks with Neutron Star Bow Shocks
The Astrophysical Journal LettersNonradiative shocks accelerate particles and heat astrophysical plasmas. While supernova remnants are the most well-studied example, neutron star (NS) bow shocks are also nonradiative and Balmer dominated.
Stella Koch Ocker, Maren Cosens
doaj +1 more source
Advanced Science, EarlyView.HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li +13 more
wiley +1 more source
Advanced Science, EarlyView.This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li +15 more
wiley +1 more source
Spindown of Pulsars Interacting with Companion Winds: The Impact of Magnetospheric Compression
The Astrophysical JournalPulsars in binary systems with strong companion winds can have the magnetopause separating their magnetosphere from the wind located well within their light cylinder.
Yici Zhong +3 more
doaj +1 more source
Advanced Science, EarlyView.Magnetoelectric nanoparticles (MENPs) enable fully wireless, minutely invasive neuromodulation, and potentially neural recording, by converting magnetic into electric and, conversely, electric into magnetic fields, respectively, at high spatiotemporal resolution.
Elric Zhang +14 more
wiley +1 more source
The JWST-NIRCam View of Sagittarius C. I. Massive Star Formation and Protostellar Outflows
The Astrophysical JournalWe present James Webb Space Telescope (JWST) Near Infrared Camera observations of the massive star-forming molecular cloud Sagittarius C (Sgr C) in the Central Molecular Zone (CMZ).
Samuel Crowe +16 more
doaj +1 more source
Temporal Interference Stimulation Enhances Neural Regeneration
Advanced Science, EarlyView.Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressotti +15 more
wiley +1 more source
Streams and Bubbles: Tidal Shaping of Hydrodynamic Planetary Outflows
The Astrophysical JournalPlanets, especially those close to their host stars, lose mass to atmospheric outflows, a process that is thought to shape the bimodal population of gaseous giant and rocky terrestrial exoplanets in close orbits.
Morgan MacLeod +3 more
doaj +1 more source