Results 61 to 70 of about 6,384 (241)
Advanced Science, EarlyView.Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su +4 more
wiley +1 more source
Interstellar Ultraviolet Lyα High Resolution Mapping from the New Horizons P-Alice Instrument
The Astronomical JournalWe present New Horizons Alice spectral observations of interstellar hydrogen Ly α emissions at a vantage point of 57 au from the Sun. The observations were conducted as a pair of orthogonal scans to produce high spatial angular resolution measurements of
Tracy M. Becker +19 more
doaj +1 more source
Summary of IAU GA SpS5 - III. Matter ejection and feedback [PDF]
, 2012 The last part of SpS5 dealt with the circumstellar environment. Structures are indeed found around several types of massive stars, such as blue and red supergiants, as well as WRs and LBVs.
Che, Xiao +10 more
core +1 more source
Advanced Science, EarlyView.This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang +21 more
wiley +1 more source
Properties of bow-shock sources at the Galactic center
, 2014 There are an enigmatic population of massive stars around the Galactic Center (GC) that were formed some Ma ago. A fraction of these stars has been found to orbit the supermassive black hole, SgrA*, in a projected clockwise disk, which suggests that they
Alberdi, A. +5 more
core +1 more source
Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome
Advanced Science, EarlyView.By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang +12 more
wiley +1 more source
Shock formation around planets orbiting M-dwarf stars
, 2011 Bow shocks can be formed around planets due to their interaction with the coronal medium of the host stars. The net velocity of the particles impacting on the planet determines the orientation of the shock. At the Earth's orbit, the (mainly radial) solar
Fossati +10 more
core +2 more sources
Thermal emission from bow shocks
Astronomy & AstrophysicsContext. X-ray emission from wind-driven bow shocks is both difficult to measure and predict, but may give important insights into the energy budget of the hot phase of the interstellar medium (ISM) by quantifying mixing at the interface between hot and warm gas phases. Aims.
Jonathan Mackey +7 more
openaire +2 more sources
Advanced Science, EarlyView.Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han +10 more
wiley +1 more source
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis
Hepatology, EarlyView., 2022 Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr +19 more
wiley +1 more source