Results 61 to 70 of about 412,900 (233)
Advanced Science, EarlyView.Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami +7 more
wiley +1 more source
Using numerical models of bow shocks to investigate the circumstellar medium of massive stars
, 2014 International audienceMany massive stars travel through the interstellar medium at supersonic speeds. As a result they form bow shocks at the interface between the stellar wind.
van Marle, Allard Jan +3 more
core +1 more source
Two More Bow Shocks and Off-center Hα Nebulae Associated with Nova-like Cataclysmic Variables
The Astronomical JournalWe report discoveries of bow-shock nebulae, seen in H α and [O iii ] λ 5007, around two cataclysmic variables (CVs): LS Pegasi and ASASSN-V J205457.73+515731.9 (ASASJ2054).
Howard E. Bond +6 more
doaj +1 more source
SAV1 in Cooperation With FKBP52 Participates in Implantation
Advanced Science, EarlyView.The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao +10 more
wiley +1 more source
Variability in Saturn's bow shock and magnetopause from pioneer and voyager: Probabilistic predictions and initial observations by Cassini [PDF]
, 2005 Probability distributions for the location of the Saturnian bow shock and magnetopause have been derived by extrapolating observations of dynamic solar wind pressures to the position of Saturn's orbit. These observations are those made by the Pioneer 11,
Hendricks, S +4 more
core
Dynamics of He++ Ions at Interplanetary and Earth’s Bow Shocks
, 2022 Experimental investigations of the fine plasma structure of interplanetary shocks are extremely difficult to conduct due to their small thickness and high speed relative to the spacecraft.
Georgii N. Zastenker +3 more
core +1 more source
Advanced Science, EarlyView.PTBP1‐mediated alternative splicing drives a pathogenic switch to the DNAJB6b isoform in everolimus‐resistant clear cell renal cell carcinoma. This splicing event programs a positive feedback loop including EIF4B/PKIB/AKT/mTOR, promoting aggressive therapy resistance.
Xiu‐wu Pan +18 more
wiley +1 more source
Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism
Advanced Science, EarlyView.Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He +7 more
wiley +1 more source
Systematic search for high-energy gamma-ray emission from bow shocks of runaway stars [PDF]
, 2014 Context. It has been suggested that the bow shocks of runaway stars are sources of high-energy gamma rays (E > 100 MeV). Theoretical models predicting high-energy gamma-ray emission from these sources were followed by the first detection of non-thermal ...
Klepser, S. +9 more
core +1 more source
Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition
Advanced Science, EarlyView.CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu +13 more
wiley +1 more source