Results 51 to 60 of about 6,384 (241)

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Modeling Nonaxisymmetric Bow Shocks: Solution Method and Exact Analytic Solutions [PDF]

, 2000
A new solution method is presented for steady-state, momentum-conserving, non-axisymmetric bow shocks and colliding winds in the thin-shell limit. This is a generalization of previous formulations to include a density gradient in the pre-shock ambient ...
Bandiera R., Baranov V. B., Canto J., Francis P. Wilkin   +3 more
core   +3 more sources

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Spindown of Pulsars Interacting with Companion Winds: The Impact of Magnetospheric Compression

The Astrophysical Journal
Pulsars in binary systems with strong companion winds can have the magnetopause separating their magnetosphere from the wind located well within their light cylinder.
Yici Zhong, Anatoly Spitkovsky, Jens F. Mahlmann, Hayk Hakobyan   +3 more
doaj   +1 more source

Exoplanet Transit Variability: Bow Shocks and Winds Around HD 189733b

, 2013
By analogy with the solar system, it is believed that stellar winds will form bow shocks around exoplanets. For hot Jupiters the bow shock will not form directly between the planet and the star, causing an asymmetric distribution of mass around the ...
Fares, R., Gombosi, T. I., Jardine, M., Llama, J, Vidotto, A. A., Wood, K.   +5 more
core   +1 more source

Magnetic Fields in Stellar Jets [PDF]

, 2007
Although several lines of evidence suggest that jets from young stars are driven magnetically from accretion disks, existing observations of field strengths in the bow shocks of these flows imply that magnetic fields play only a minor role in the ...
Adam Frank, Bacciotti F., Casse F., Eric G. Blackman, O’Sullivan S., Patrick Hartigan, Peggy Varniere   +6 more
core   +4 more sources

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

The JWST-NIRCam View of Sagittarius C. I. Massive Star Formation and Protostellar Outflows

The Astrophysical Journal
We present James Webb Space Telescope (JWST) Near Infrared Camera observations of the massive star-forming molecular cloud Sagittarius C (Sgr C) in the Central Molecular Zone (CMZ).
Samuel Crowe, Rubén Fedriani, Jonathan C. Tan, Alva Kinman, Yichen Zhang, Morten Andersen, Lucía Bravo Ferres, Francisco Nogueras-Lara, Rainer Schödel, John Bally, Adam Ginsburg, Yu Cheng, Yao-Lun Yang, Sarah Kendrew, Chi-Yan Law, Joseph Armstrong, Zhi-Yun Li   +16 more
doaj   +1 more source

Beyond CD30: Dual‐Targeting of Malignant and Regulatory T Cells by Brentuximab Vedotin Remodels the Lymphoma Microenvironment and Overcomes Resistance via BCL2 Inhibition in Mycosis Fungoides

Advanced Science, EarlyView.
Single‐cell RNA analyses of paired lesions from CD30+ mycosis fungoides patients demonstrate that brentuximab vedotin (BV) induces immunogenic cell death in both CD30+ and CD30− malignant T cells. BV also targets regulatory T cells and remodels tumor microenvironment, while resistance is driven by impaired IFN responses, drug efflux, and BCL2 ...
Yi Jiang, Pan Lai, Mingjia Li, Yujie Wen, Mengzhou Cao, Yu Xiao, Zhuojing Chen, Jingru Sun, Yang Wang   +8 more
wiley   +1 more source

Streams and Bubbles: Tidal Shaping of Hydrodynamic Planetary Outflows

The Astrophysical Journal
Planets, especially those close to their host stars, lose mass to atmospheric outflows, a process that is thought to shape the bimodal population of gaseous giant and rocky terrestrial exoplanets in close orbits.
Morgan MacLeod, Antonija Oklopčić, Fabienne Nail, Dion Linssen   +3 more
doaj   +1 more source