Results 91 to 100 of about 2,514,308 (344)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Asteroseismic classification of stellar populations among 13000 red giants observed by Kepler

, 2013
Of the more than 150000 targets followed by the Kepler Mission, about 10% were selected as red giants. Due to their high scientific value, in particular for Galaxy population studies and stellar structure and evolution, their Kepler light curves were ...
Bedding, T. R., Benomar, O., Bildsten, L., Elsworth, Y. P., Gilliland, R. L., Huber, D., Mosser, B., Paxton, B., Stello, D., White, T. R.   +9 more
core   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

starkiller: Subtracting Stars and Other Sources from IFU Spectroscopic Data Through Forward Modeling

The Astronomical Journal
We present starkiller , an open-source Python package for forward-modeling flux retrieval from integral field unit (IFU) spectrograph data cubes. starkiller simultaneously provides stellar spectral classification, relative velocity, and line-of-sight ...
Ryan Ridden-Harper, Michele T. Bannister, Sophie E. Deam, Thomas Nordlander   +3 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

OB stars at the lowest Local Group metallicity: GTC-OSIRIS observations of Sextans A

, 2015
Our aim is to find and classify OB stars in Sextans A, to later determine accurate stellar parameters of these blue massive stars in this low metallicity region $(Z \sim 0.1 \rm Z_{\odot})$.
Camacho, I., Garcia, M., Herrero, A., Simón-Díaz, S.   +3 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Seeking Spectroscopic Binaries with Data-driven Models

The Astrophysical Journal
Data-driven stellar classification has a long and important history in astronomy, dating as far back as Annie Jump Cannon’s “by-eye” classifications of stars into spectral types, still used today.
Isabel Angelo, Erik Petigura, Megan Bedell   +2 more
doaj   +1 more source