Results 111 to 120 of about 12,062 (300)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
A Deep, High-angular-resolution 3D Dust Map of the Southern Galactic Plane
The Astrophysical JournalWe present a deep, high-angular-resolution 3D dust map of the southern Galactic plane over 239°
Catherine Zucker +10 more
doaj +1 more source
Astronomy & AstrophysicsUnderstanding supernova (SN) progenitors remains a major challenge in astrophysics, as it involves untangling the complex interplay between stellar physics (e.g. evolution, binarity, and explosion) and environments (e.g.
Gutiérrez Claudia P. +6 more
doaj +1 more source
AN EMPIRICAL TOOL TO DERIVE METALLICITY, REDDENING, AND DISTANCE FOR OLD STELLAR POPULATIONS FROM NEAR-INFRARED COLOR-MAGNITUDE DIAGRAMS 1 [PDF]
, 2020 We present an empirical method to derive photometric metallicity, reddening, and distance to old stellar populations by using a few major features of the red giant branch (RGB) in near-IR color-magnitude diagrams.
Francesco R Ferraro +2 more
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The Astrophysical JournalIn NGC 2992, a galaxy-scale ionized gas outflow driven by active galactic nuclei (AGNs) has long been recognized, yet its impact on the host galaxy has remained elusive.
Xiaoyu Xu +3 more
doaj +1 more source
The Impact of Stellar Distances on Habitable Zone Planets [PDF]
The Astrophysical Journal Letters, 2018 Abstract Among the most highly valued of exoplanetary discoveries are those of terrestrial planets found to reside within the habitable zone (HZ) of the host star. In particular, those HZ planets with relatively bright host stars will serve as priority targets for characterization observations, such as those involving mass determinations,
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source