Results 111 to 120 of about 1,747,943 (295)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Relative frequencies of core-collapse supernovae as a function of metallicity: Observations versus theoretical predictions

Astronomy & Astrophysics
Understanding supernova (SN) progenitors remains a major challenge in astrophysics, as it involves untangling the complex interplay between stellar physics (e.g. evolution, binarity, and explosion) and environments (e.g.
Gutiérrez Claudia P., Galbany Lluís, Anderson Joseph P., Souropanis Dimitris, Zapartas Emmanouil, Dessart Luc, Kotak Rubina   +6 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatially Resolved Analysis of Stellar Populations in NGC 2992: Impact of Active Galactic Nucleus Feedback

The Astrophysical Journal
In NGC 2992, a galaxy-scale ionized gas outflow driven by active galactic nuclei (AGNs) has long been recognized, yet its impact on the host galaxy has remained elusive.
Xiaoyu Xu, Junfeng Wang, Zhiyuan Li, Yanmei Chen   +3 more
doaj   +1 more source

Exploring the use of distance education technology for lifestyle change

, 2011
Obesity affects over 100 million men, women, and children in North America alone and has reached what health professionals deem to be epidemic proportions.
Patrick J. Tierney
core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Large Magellanic Cloud Globular Clusters in the Near-infrared. I. RR Lyrae in Reticulum

The Astronomical Journal
Reticulum is an old, metal-poor, and sparsely populated globular cluster in the outer regions of the Large Magellanic Cloud (LMC) and hosts a rich population of RR Lyrae stars.
Anupam Bhardwaj, Susmita Das, Prashant Nishad, Marina Rejkuba, Giulia De Somma, Marcella Marconi, Chow-Choong Ngeow, Vincenzo Ripepi, Sarang Shah, Subhajit Kar, Shashi Kanbur, Matteo Monelli, Massimo Dall’Ora   +12 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Wolf–Rayet stars as tracers of gamma-ray emission

Astronomy & Astrophysics
Context. Recent gamma-ray observations of young star clusters revealed that stellar wind termination shocks accelerate particles. The energy reservoir for particle acceleration is provided by the wind mechanical power of cluster member stars. Aims.
Inventar A., Peron G., Recchia S., Gabici S.   +3 more
doaj   +1 more source