Results 101 to 110 of about 1,747,943 (295)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Imaging Magnetically Driven Astrospheres: A Forward Modeling Approach

The Astrophysical Journal Letters
An astrosphere is a vast, tailed, bubble-like volume around a star, formed through the interaction between the stellar magnetic field, the stellar wind, and the interstellar medium (ISM).
Ziqi Wu, Tom Van Doorsselaere, Jiansen He, Hugues Sana, Nicholas Jannsen, Tianhang Chen, Weining Wang, Zheng Sun   +7 more
doaj   +1 more source

Important considerations of Stellar distance indicators

, 2020
Periodic luminous pulses are very important for measurements in Cosmology and Astrophysics, and there are very specific methods and sources which exhibit such properties. Stellar astrophysics provides a number of observational and mathematical sources which give a very important tool in understanding the dynamics of an expanding Universe, and in this ...
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The nature and origin of disky elliptical galaxies [PDF]

, 2002
The observational trend that disky elliptical galaxies exhibit younger luminosity- weighted ages than boxy ellipticals is investigated. The presence of a possible young stellar disk embedded in these galaxies is explored by comparing kinematics derived ...
McDermid, Richard Morgan
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

photoD with Rubin’s Data Preview 1: First stellar photometric distances and faint blue star deficits

Astronomy & Astrophysics
Aims. We investigate the utility of Rubin’s Data Preview 1 (DP1) for estimating stellar number density profiles across the Milky Way halo. Methods.
Palaversa L., Donev E., Ivezić Ž., Mrakovčić K., Caplar N., Jurićc M., Jurkić T., Campos S., DeLucchi M., Jones D., Malanchev K., Malz A. I., McGuire S., Abel B., Girardi L., Pastorelli G., Trabucchi M., Zaggia S., Acosta E., Adair C. L., Andrew J., Aubourg É., Bauer A. E., Beebe W., Bellm E. C., Blum R. D., Booth M. T., Boucaud A., Branton D., Burke D. L., Calabrese D., Carlin J. L., Chiang H.-F., Choi Y., Connolly A. J., Dagoret-Campagne S., Daly P. N., Daruich F., Daubard G., Dennihy E., Drass H., Eiger O., Eisner A. M., Guy L. P., Hoblitt J., Ingraham P., Jammes F., Jannuzi B. T., Jee M. J., Jenness T., Jones R. L., Juramy-Gilles C., Kahn S. M., Kang Y., Kannawadi A., Kelvin L. S., Kotov I. V., Kovács G., Kurita N. R., Lange T., Laporte D., Lazarte J. C., Liang S., Lopez M., Lust N. B., Lutfi M., Lynn O., Mainetti G., Menanteau F., Miller M., Moniez M., Nourbakhsh E., Park H. Y., Peterson J. R., Plante R., Plazas Malagón A. A., Porter M. N., Reil K. A., Riot V. J., Roodman A., Rykoff E. S., Schindler R. H., Sebag J., Sedaghat N., Shaw R. A., Shugart A., Siruno K. B., Smith J. A., Swinbank J. D., Thayer J. G., Thomas S., Tighe R., Tucker D. L., Turri M., Urbach E. K., Van Klaveren B., van Reeven W., Waters C. Z., Willman B.   +98 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

A Deep, High-angular-resolution 3D Dust Map of the Southern Galactic Plane

The Astrophysical Journal
We present a deep, high-angular-resolution 3D dust map of the southern Galactic plane over 239° 
Catherine Zucker, Andrew K. Saydjari, Joshua S. Speagle, Edward F. Schlafly, Gregory M. Green, Robert Benjamin, Joshua Peek, Gordian Edenhofer, Alyssa Goodman, Michael A. Kuhn, Douglas P. Finkbeiner   +10 more
doaj   +1 more source